Accepted manuscript
A General Strategy for Development of Near-Infrared Fluorescent Probes for Bioimaging
Angewandte Chemie (International ed.), Vol.56(52), pp.16611-16615
12/22/2017
Handle:
https://hdl.handle.net/2376/113076
PMCID: PMC5773255
PMID: 29134784
Abstract
Near-infrared (NIR) fluorescent dyes with favorable photophysical properties are highly useful for bioimaging,but such dyes are still rare.T he development of au nique class of NIR dyes via modifying the rhodol scaffold with fused tetrahydroquinoxaline rings is described. These new dyes showed large Stokes shifts (> 110 nm). Among them, WR3, WR4, WR5, and WR6 displayed high fluorescence quantum yields and excellent photostability in aqueous solutions.More-over,t heir fluorescence properties were tunable by easy modifications on the phenolic hydroxy group.B ased on WR6, two NIR fluorescent turn-on probes,W SP-NIR and SeSP-NIR, were devised for the detection of H 2 S. The probe SeSP-NIR was applied in visualizing intracellular H 2 S. These dyes are expected to be useful fluorophore scaffolds in the development of new NIR probes for bioimaging.
Metrics
1 File views/ downloads
18 Record Views
Details
- Title
- A General Strategy for Development of Near-Infrared Fluorescent Probes for Bioimaging
- Creators
- Wei Chen - Department of Chemistry; Washington State University; Pullman WA 99164 USAShi Xu - Department of Chemistry; Washington State University; Pullman WA 99164 USAJacob J Day - Department of Chemistry; Washington State University; Pullman WA 99164 USADifei Wang - Division of Cancer Epidemiology and Genetics, NCI; NIH; Rockville MD 20850 USAMing Xian - Department of Chemistry; Washington State University; Pullman WA 99164 USA
- Publication Details
- Angewandte Chemie (International ed.), Vol.56(52), pp.16611-16615
- Academic Unit
- Department of Chemistry
- Publisher
- Wiley
- Number of pages
- 5
- Grant note
- R01HL116571 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01HL116571; 1F31HL137233 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA CHE1738305 / NSF; National Science Foundation (NSF)
- Identifiers
- 99900547404801842
- Language
- English
- Resource Type
- Accepted manuscript