Accepted manuscript
A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers
Cancer epidemiology, biomarkers & prevention, Vol.20(4), pp.658-664
2011
Handle:
https://hdl.handle.net/2376/106523
PMID: 21335511
Abstract
Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR ¼ 1.24, P ¼ 0.003) with little effect in men (OR ¼ 1.04, P ¼ 0.35). Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case–control studies. Results: rs16969968 was again associated with UADT cancers in women (OR ¼ 1.21, 95% CI ¼ 1.08–1.36, P ¼ 0.001) and a similar lack of observed effect in men [OR ¼ 1.02, 95% CI ¼ 0.95–1.09, P ¼ 0.66; P-heterogeneity (P het) ¼ 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR ¼ 1.22, 95% CI ¼ 1.12–1.34, P ¼ 7 Â 10 À6) but not males (OR ¼ 1.02, 95% CI ¼ 0.97–1.08, P ¼ 0.35; P het ¼ 6 Â 10 À4). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P het ¼ 0.86). Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. Impact: Further research is warranted to elucidate the mechanisms underlying these observations. Cancer Epidemiol Biomarkers Prev; 20(4); 658–64. Ó2011 AACR.
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- Title
- A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers
- Creators
- DAN DAN CHEN - International Agency for Research on Cancer (IARC), Lyon, FrancePhilip LAZARUS - Penn State College of Medicine, Hershey, Pennsylvania, United StatesTherese TRUONG - International Agency for Research on Cancer (IARC), Lyon, FranceShama BUCH - University of Pittsburgh, Pittsburgh, Pennsylvania, United StatesTomoko NUKUI - University of Pittsburgh, Pittsburgh, Pennsylvania, United StatesSilvia FRANCESCHI - International Agency for Research on Cancer (IARC), Lyon, FranceRolando HERRERO - Instituto de Investigación Epidemiológica, San José, Costa Rica, United StatesRenato TALAMINI - National Cancer Institute, IRCSS, Aviano, ItalyKarl T KELSEY - Brown University, Providence, Rhode Island, United StatesBrock CHRISTENSEN - Brown University, Providence, Rhode Island, United StatesMichael D MCCLEAN - Boston University School of Public Health, Boston, Massachusetts, United StatesMartin LACKO - Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Site, Maastricht, NetherlandsJohannes J MANNI - Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Site, Maastricht, NetherlandsValerie GABORIEAU - International Agency for Research on Cancer (IARC), Lyon, FranceWilbert H. M PETERS - Department of Gastroenterology, Radboud University Nijmegen Medical Site, Nijmegen, NetherlandsJan LUBINSKI - Pomeranian Medical University, Department of Genetics and Pathomorphology, International Hereditary Cancer Site, Szczecin, PolandJoanna TRUBICKA - Pomeranian Medical University, Department of Genetics and Pathomorphology, International Hereditary Cancer Site, Szczecin, PolandMarcin LENER - Pomeranian Medical University, Department of Genetics and Pathomorphology, International Hereditary Cancer Site, Szczecin, PolandJoshua E MUSCAT - Penn State College of Medicine, Hershey, Pennsylvania, United StatesQINGYI QINGYI WEI - University of Texas MD Anderson Cancer Site, Houston, Texas, United StatesErich M STURGIS - University of Texas MD Anderson Cancer Site, Houston, Texas, United StatesZuo-Feng ZHANG - University of California, Los Angeles, School of Public Health, Los Angeles, California, United StatesShen-Chih CHANG - University of California, Los Angeles, School of Public Health, Los Angeles, California, United StatesGraham BYRNES - International Agency for Research on Cancer (IARC), Lyon, FranceRENYI RENYI WANG - University of California, Los Angeles, School of Public Health, Los Angeles, California, United StatesStephen M SCHWARTZ - Fred Hutchinson Cancer Research Site, Seattle, Washington, United StatesCHU CHU CHEN - Fred Hutchinson Cancer Research Site, Seattle, Washington, United StatesSimone BENHAMOU - INSERM U946, Paris, FrancePagona LAGIOU - University of Athens School of Medicine, Athens, GreeceIvana HOLCATOVA - Institute of Hygiene and Epidemiologyy,1st Faculty of Medicine, Charles University, Prague, Czech RepublicLorenzo RICHIARDI - Unit of Cancer Epidemiology, University of Turin, Turin, ItalyKristina KJAERHEIM - Cancer Registry of Norway, Oslo, NorwayAntonio AGUDO - Institut Català d'Oncologia (ICO), Barcelona, SpainXavier CASTELLSAGUE - Institut Català d'Oncologia (ICO), Barcelona, SpainAmelie CHABRIER - International Agency for Research on Cancer (IARC), Lyon, FranceTatianaV MACFARLANE - International Agency for Research on Cancer (IARC), Lyon, FranceLuigi BARZAN - International Agency for Research on Cancer (IARC), Lyon, FranceCristina CANOVA - International Agency for Research on Cancer (IARC), Lyon, FranceNalin S THAKKER - International Agency for Research on Cancer (IARC), Lyon, FranceDavid I CONWAY - International Agency for Research on Cancer (IARC), Lyon, FranceAriana ZNAOR - International Agency for Research on Cancer (IARC), Lyon, FranceClaire M HEALY - International Agency for Research on Cancer (IARC), Lyon, FranceWolfgang AHRENS - International Agency for Research on Cancer (IARC), Lyon, FranceDavid ZARIDZE - International Agency for Research on Cancer (IARC), Lyon, FranceNeonila SZESZENIA-DABROWSKA - International Agency for Research on Cancer (IARC), Lyon, FranceShu-Chun CHUANG - International Agency for Research on Cancer (IARC), Lyon, FranceJolanta LISSOWSKA - International Agency for Research on Cancer (IARC), Lyon, FranceEleonora FABIANOVA - International Agency for Research on Cancer (IARC), Lyon, FranceAlexandru BUCUR - International Agency for Research on Cancer (IARC), Lyon, FranceVladimir BENCKO - Institute of Hygiene and Epidemiologyy,1st Faculty of Medicine, Charles University, Prague, Czech RepublicLenka FORETOVA - International Agency for Research on Cancer (IARC), Lyon, FranceVladimir JANOUT - International Agency for Research on Cancer (IARC), Lyon, FranceMaria Paula CURADO - International Agency for Research on Cancer (IARC), Lyon, FranceSergio KOIFMAN - International Agency for Research on Cancer (IARC), Lyon, FranceAna MENEZES - International Agency for Research on Cancer (IARC), Lyon, FranceVictor WUNSCH-FILHO - International Agency for Research on Cancer (IARC), Lyon, FranceAndrew F OLSHAN - Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United StatesMark C WEISSLER - Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United StatesJINGCHUN JINGCHUN LUO - Lineberger Comprehensive Cancer Site, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United StatesMarjorie ROMKES - University of Pittsburgh, Pittsburgh, Pennsylvania, United States
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.20(4), pp.658-664
- Academic Unit
- Department of Pharmaceutical Sciences
- Publisher
- American Association for Cancer Research; Philadelphia, PA
- Number of pages
- 7
- Grant note
- G0801056 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) T32CA009142 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 1R03DE020116-01 / National Institute of Dental and Craniofacial Research; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) R01 CA092039 05/05S1 / U.S. National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Identifiers
- 99900546968201842
- Language
- English
- Resource Type
- Accepted manuscript