Accepted manuscript
A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals
Angewandte Chemie (International ed.), Vol.55(34), pp.9993-9996
08/16/2016
Handle:
https://hdl.handle.net/2376/111175
PMCID: PMC5166716
PMID: 27410794
Abstract
Hydrogen sulfide (H 2 S) and hydrogen polysulfides (H 2 S n , n > 1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship and cellular cross-talk between H 2 S and H 2 S n , it is highly desirable to develop single fluorescent probes which enable dual-channel discrimination between H 2 S and H 2 S n . Herein we report the rational design, synthesis, and evaluation of the first dual-detection fluorescent probe DDP-1 that can visualize H 2 S and H 2 S n with different fluorescence signals. The probe showed high selectivity and sensitivity to H 2 S and H 2 S n in aqueous media and in cells. The first single fluorescent probe DDP-1 that can visualize H 2 S and H 2 S n with different emission channels was discovered. H 2 S can be identified by the simultaneous appearance of two fluorescence signals in blue and green channels, whereas H 2 S n can be characterized by the single emission in green channel
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Details
- Title
- A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals
- Creators
- Wei Chen - Department of Chemistry, Washington State University, Pullman, WA 99164 (USA)Armando Pacheco - Department of Chemistry, Washington State University, Pullman, WA 99164 (USA)Yoko Takano - Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033(Japan)Jacob J Day - Department of Chemistry, Washington State University, Pullman, WA 99164 (USA)Kenjiro Hanaoka - Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033(Japan)Ming Xian - Department of Chemistry, Washington State University, Pullman, WA 99164 (USA)
- Publication Details
- Angewandte Chemie (International ed.), Vol.55(34), pp.9993-9996
- Academic Unit
- Chemistry, Department of
- Publisher
- Wiley
- Number of pages
- 4
- Grant note
- R01HL116571 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01HL116571 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Identifiers
- 99900547349801842
- Language
- English
- Resource Type
- Accepted manuscript