Accepted manuscript
A metabolic-transcriptional network links sleep and cellular energetics in the brain
Pflügers Archiv, Vol.463(1), pp.15-22
01/2012
Handle:
https://hdl.handle.net/2376/101111
PMCID: PMC4086657
PMID: 21927810
Abstract
This review proposes a mechanistic link between cellular metabolic status, transcriptional regulatory changes and sleep. Sleep loss is associated with changes in cellular metabolic status in the brain. Metabolic sensors responsive to cellular metabolic status regulate the circadian clock transcriptional network. Modifications of the transcriptional activity of circadian clock genes affect sleep/wake state changes. Changes in sleep state reverse sleep loss-induced changes in cellular metabolic status. It is thus proposed that the regulation of circadian clock genes by cellular metabolic sensors is a critical intermediate step in the link between cellular metabolic status and sleep. Studies of this regulatory relationship may offer insights into the function of sleep at the cellular level.
Metrics
21 Record Views
Details
- Title
- A metabolic-transcriptional network links sleep and cellular energetics in the brain
- Creators
- Jonathan P Wisor - WWAMI Medical Education Program and Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Spokane, WA, USA. J_Wisor@wsu.edu
- Publication Details
- Pflügers Archiv, Vol.463(1), pp.15-22
- Academic Unit
- Department of Biomedical Sciences
- Publisher
- Germany
- Grant note
- R15 NS070734 / NINDS NIH HHS R15 NS070734-01 / NINDS NIH HHS 1R15NS070734 / NINDS NIH HHS
- Identifiers
- 99900546521401842
- Language
- English
- Resource Type
- Accepted manuscript