Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Emanuele Leoncini; Philip Lazarus; Walter Ricciardi; Gabriella Cadoni; Dario Arzani; Livia Petrelli; Gaetano Paludetti; Paul Brennan; Daniele Luce; Isabelle Stucker; Keitaro Matsuo; Renato Talamini; Carlo La Vecchia; Andrew F Olshan; Deborah M Winn; Rolando Herrero; Silvia Franceschi; Xavier Castellsague; Joshua Muscat; Hal Morgenstern; Zuo-Feng Zhang; Fabio Levi; Luigino Dal Maso; Karl Kelsey; Michael McClean; Thomas L Vaughan; Mark P Purdue; Richard B Hayes; Chu Chen; Stephen M Schwartz; Oxana Shangina; Sergio Koifman; Wolfgang Ahrens; Elena Matos; Pagona Lagiou; Jolanta Lissowska; Neonila Szeszenia-Dabrowska; Leticia Fernandez; Ana Menezes; Antonio Agudo; Alexander W Daudt; Lorenzo Richiardi; Kristina Kjaerheim; Dana Mates; Jaroslav Betka; Guo-Pei Yu; Stimson Schantz; Lorenzo Simonato; Hermann Brenner; David I Conway; Tatiana V Macfarlane; Peter Thomson; Eleonora Fabianova; Ariana Znaor; Peter Rudnai; Claire Healy; Paolo Boffetta; Shu-Chun Chuang; Yuan-Chin Amy Lee; Mia Hashibe; Stefania Boccia

doi:10.1007/s10654-013-9863-2

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Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

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Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Emanuele Leoncini, Philip Lazarus, Walter Ricciardi, Gabriella Cadoni, Dario Arzani, Livia Petrelli, Gaetano Paludetti, Paul Brennan, Daniele Luce, Isabelle Stucker, …

European journal of epidemiology, Vol.29(1), pp.35-48

01/2014

DOI: https://doi.org/10.1007/s10654-013-9863-2

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https://hdl.handle.net/2376/109871

PMCID: PMC4122122

PMID: 24271556

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Abstract

Life Sciences & Biomedicine

Public, Environmental & Occupational Health

Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

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Title: Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium
Creators: Emanuele Leoncini - Section of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy
Philip Lazarus - Penn State College of Medicine, Hershey, PA, USA
Walter Ricciardi - Section of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy
Gabriella Cadoni - Institute of Otorhinolaryngology, Università Cattolica del Sacro Cuore, Rome, Italy
Dario Arzani - Section of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy
Livia Petrelli - Institute of Otorhinolaryngology, Università Cattolica del Sacro Cuore, Rome, Italy
Gaetano Paludetti - Institute of Otorhinolaryngology, Università Cattolica del Sacro Cuore, Rome, Italy
Paul Brennan - International Agency for Research on Cancer, Lyon, France
Daniele Luce - INSERM UMRS 1018, Centre for research in Epidemiology and Population Health, Villejuif, France
Isabelle Stucker - INSERM UMRS 1018, Centre for research in Epidemiology and Population Health, Villejuif, France
Keitaro Matsuo - Aichi Cancer Center Research Institute, Nagoya, Japan
Renato Talamini - Centro di Riferimento Oncologico IRCCS, Aviano, Italy
Carlo La Vecchia - Istituto di Ricerche Farmacologiche Mario Negri and University of Milan, Milan, Italy
Andrew F Olshan - University of North Carolina School of Public Health, Chapel Hill, NC, USA
Deborah M Winn - National Cancer Institute, Bethesda, MD, USA
Rolando Herrero - International Agency for Research on Cancer, Lyon, France
Silvia Franceschi - International Agency for Research on Cancer, Lyon, France
Xavier Castellsague - Institut Catala d’Oncologia (ICO), IDIBELL, CIBER-ESP, L’Hospitalet de Llobregat, Spain
Joshua Muscat - Penn State College of Medicine, Hershey, PA, USA
Hal Morgenstern - Departments of Epidemiology and Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA
Zuo-Feng Zhang - Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA
Fabio Levi - Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland
Luigino Dal Maso - Centro di Riferimento Oncologico IRCCS, Aviano, Italy
Karl Kelsey - Brown University, Providence, Rhode Island, USA
Michael McClean - Boston University School of Public Health, Boston, MA
Thomas L Vaughan - Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Mark P Purdue - National Cancer Institute, Bethesda, MD, USA
Richard B Hayes - Division of Epidemiology, New York University School Of Medicine, NY, New York, USA
Chu Chen - Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Stephen M Schwartz - Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Oxana Shangina - Cancer Research Centre, Moscow, Russia
Sergio Koifman - Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
Wolfgang Ahrens - Bremen Institute for Prevention Research and Social Medicine (BIPS), Bremen, Germany
Elena Matos - Institute of Oncology Angel H. Roffo, University of Buenos Aires, Argentina
Pagona Lagiou - University of Athens School of Medicine, Athens, Greece
Jolanta Lissowska - M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Dept. of Cancer Epidemiology and Prevention, Warsaw, Poland
Neonila Szeszenia-Dabrowska - Institute of Occupational Medicine, Lodz, Poland
Leticia Fernandez - Institute of Oncology and Radiobiology, Havana, Cuba
Ana Menezes - Universidade Federal de Pelotas, Pelotas, Brazil
Antonio Agudo - Catalan Institute of Oncology (ICO), IDIBELL, L’Hospitalet de Llobregat, Spain
Alexander W Daudt - Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
Lorenzo Richiardi - Department of Medical Sciences, University of Turin, Italy
Kristina Kjaerheim - Cancer Registry of Norway, Oslo, Norway
Dana Mates - Institute of Public Health, Bucharest, Romania
Jaroslav Betka - Department of Otorhinolaryngology, Head and Neck Surgery, First Faculty of Medicine, Charles University in Prague and University Hospital Motol, Czech Republic
Guo-Pei Yu - New York Eye and Ear Infirmary, New York, NY, USA
Stimson Schantz - New York Eye and Ear Infirmary, New York, NY, USA
Lorenzo Simonato - University of Padua, Padova, Italy
Hermann Brenner - German Cancer Research Center, Division of Clinical Epidemiology and Aging Research
David I Conway - Dental School, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
Tatiana V Macfarlane - University of Aberdeen Dental School, Aberdeen, UK
Peter Thomson - University of Newcastle, Newcastle, UK
Eleonora Fabianova - Regional Authority of Public Health in Banska Bystrica, Slovakia
Ariana Znaor - Croatian National Cancer Registry, Zagreb, Croatia
Peter Rudnai - National Institute of Environmental Health, Budapest, Hungary
Claire Healy - Trinity College School of Dental Science, Dublin, Ireland
Paolo Boffetta - The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA
Shu-Chun Chuang - Imperial College London, UK
Yuan-Chin Amy Lee - Department of Family & Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT
Mia Hashibe - Department of Family & Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT
Stefania Boccia - Section of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy
Publication Details: European journal of epidemiology, Vol.29(1), pp.35-48
Academic Unit: Department of Pharmaceutical Sciences
Publisher: Springer Nature
Number of pages: 14
Grant note: R01CA078609; R01CA100679 / National Institutes of Health (NIH) US; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 10491 / AIRC (Italian Agency for Research on Cancer); Fondazione AIRC per la ricerca sul cancro P30ES010126 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) Italian Ministry of Research; Ministry of Education, Universities and Research (MIUR) Swiss League against Cancer R01CA051845; R01CA030022 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P50CA090388; R01DA011386; R03CA077954; T32CA009142; U01CA096134; R21ES011667; P01CA068384 K07CA104231; R01CA061188; R01CA048996; R01DE012609; P01CA068384; K07CA104231; R01DE013158 / National Institute of Health (NIH) US; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; Office of the Administrator (NIH) Italian Association for Research on Cancer (AIRC); Fondazione AIRC per la ricerca sul cancro French Association for Research on Cancer (ARC) 17015052 / Ministry of Education, Science, Sports, Culture and Technology of Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
Identifiers: 99900547006801842
Language: English
Resource Type: Accepted manuscript