Accepted manuscript
An Examination of Male and Female Odds Ratios by BMI, Cigarette Smoking and Alcohol Consumption for Cancers of the Oral Cavity, Pharynx and Larynx in Pooled Data from 15 Case-Control Studies
Cancer causes & control, Vol.22(9), pp.1217-1231
09/2011
Handle:
https://hdl.handle.net/2376/100625
PMCID: PMC3304584
PMID: 21744095
Abstract
Greater tobacco smoking and alcohol consumption and lower body mass index (BMI) increase odds ratios (OR) for oral cavity, oropharyngeal, hypopharyngeal, and laryngeal cancers; however, there are no comprehensive sex-specific comparisons of ORs for these factors.
We analyzed 2,441 oral cavity (925 women and 1,516 men), 2,297 oropharynx (564 women and 1,733 men), 508 hypopharynx (96 women and 412 men), and 1,740 larynx (237 women and 1,503 men) cases from the INHANCE consortium of 15 head and neck cancer case-control studies. Controls numbered from 7,604 to 13,829 subjects, depending on analysis. Analyses fitted linear-exponential excess ORs models.
ORs were increased in underweight (< 18.5 BMI) relative to normal weight (18.5-24.9) and reduced in overweight and obese categories (a parts per thousand yen25 BMI) for all sites and were homogeneous by sex. ORs by smoking and drinking in women compared with men were significantly greater for oropharyngeal cancer (p < 0.01 for both factors), suggestive for hypopharyngeal cancer (p = 0.05 and p = 0.06, respectively), but homogeneous for oral cavity (p = 0.56 and p = 0.64) and laryngeal (p = 0.18 and p = 0.72) cancers.
The extent that OR modifications of smoking and drinking by sex for oropharyngeal and, possibly, hypopharyngeal cancers represent true associations, or derive from unmeasured confounders or unobserved sex-related disease subtypes (e.g., human papillomavirus-positive oropharyngeal cancer) remains to be clarified.
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- Title
- An Examination of Male and Female Odds Ratios by BMI, Cigarette Smoking and Alcohol Consumption for Cancers of the Oral Cavity, Pharynx and Larynx in Pooled Data from 15 Case-Control Studies
- Creators
- Jay H Lubin - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USAJoshua Muscat - Penn State College of Medicine, Hershey, PA, USAMia M Gaudet - Epidemiology Research Program, American Cancer Society, Atlanta, GA, USAAndrew F Olshan - Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NCMaria Paula Curado - International Agency for Research on Cancer, Lyon, FranceLuigino Dal Maso - Epidemiology and Biostatistics Unit, Aviano Cancer Centre, Aviano, ItalyVictor Wünsch-Filho - Universidade de Sao Paulo, Sao Paulo, BrazilErich M Sturgis - UT-M.D. Anderson Cancer Center, Houston, Texas, USANeonilia Szeszenia-Dabrowska - Institute of Occupational Medicine, Lodz, PolandXavier Castellsague - Institut Català d’Oncologia (ICO), IDIBELL, CIBER-ESP, L’Hospitalet de Llobregat, Barcelona, SpainZuo-Feng Zhang - UCLA School of Public Health, Los Angeles, CA, USAElaine Smith - College of Public Health, University of Iowa, Iowa City, IA, USALeticia Fernandez - Institute of Oncology and Radiobiology, Havana, CubaElena Matos - Institute of Oncology Angel H. Roffo, University of Buenos Aires, Argentina21. Universidade Federal de Pelotas, Pelotas, BrazilSilvia Franceschi - International Agency for Research on Cancer, Lyon, FranceEleonora Fabianova - Specialized State Health Institute, Banská Bystrica, SlovakiaPeter Rudnai - National Institute of Environmental Health, Budapest, HungaryMark P Purdue - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USADana Mates - Occupational Health Department, Institute of Public Health, Bucharest, RomaniaQingyi Wei - UT-M.D. Anderson Cancer Center, Houston, Texas, USARolando Herrero - Instituto de Investigación Epidemiológica, San José, Costa RicaKarl Kelsey - Brown University, Bio Medical Center for Environmental Health and Technology, Providence, RI, USAHal Morgenstern - Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USAOxana Shangina - Cancer Research Centre, Moscow, RussiaSergio Koifman - Escola Nacional de Saude Publica, Fundaçao Oswaldo Cruz, Rio de Janeiro, BrazilJolanta Lissowska - The M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Dept. of Cancer Epidemiology and Prevention, Warsaw, PolandFabio Levi - Institut de médecine sociale et préventive, Université de Lausanne, Lausanne, SwitzerlandAlexander W Daudt - Hospital de Clinicas de Porto Alegre, Porto Alegre, BrazilJose Eluf Neto - Universidade de Sao Paulo, Sao Paulo, BrazilChu Chen - Fred Hutchinson Cancer Research Center, Seattle, WA, USAPhilip Lazarus - Penn State College of Medicine, Hershey, PA, USADeborah M Winn - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USAStephen M Schwartz - Fred Hutchinson Cancer Research Center, Seattle, WA, USAPaolo Boffetta - International Agency for Research on Cancer, Lyon, FrancePaul Brennan - International Agency for Research on Cancer, Lyon, FranceAna Menezes - Universidade Federal de Pelotas, Pelotas, BrazilCarlo La Vecchia - Istituto di Ricerche Farmacologiche Mario Negri and University of Milan, Milan, ItalyMichael McClean - Boston University School of Public Health, Boston, MARenato Talamini - Epidemiology and Biostatistics Unit, Aviano Cancer Centre, Aviano, ItalyThangarajan Rajkumar - Department of Molecular Oncology, Cancer Institute (WIA), Adyar, Chennai, IndiaRichard B Hayes - Division of Epidemiology, New York University, Langone Medical Center, New York, NY, USAMia Hashibe - Department of Family and Preventive Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA
- Publication Details
- Cancer causes & control, Vol.22(9), pp.1217-1231
- Academic Unit
- Department of Pharmaceutical Sciences
- Publisher
- Springer Nature
- Number of pages
- 15
- Grant note
- P30 ES010126-11 || ES / National Institute of Environmental Health Sciences : NIEHS
- Identifiers
- 99900546691701842
- Language
- English
- Resource Type
- Accepted manuscript