Accepted manuscript
Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature
Differentiation (London), Vol.80(1), pp.1-8
2010
Handle:
https://hdl.handle.net/2376/105416
PMCID: PMC2894270
PMID: 20219281
Abstract
A phylogenetic analysis of the basic helix-loop-helix (bHLH) gene superfamily was performed using seven different species (human, mouse, rat, worm, fly, yeast, and plant Arabidopsis) and involving over 600 bHLH genes ( Stevens et al., 2008). All bHLH genes were identified in the genomes of the various species, including expressed sequence tags, and the entire coding sequence was used in the analysis. Nearly 15% of the gene family has been updated or added since the original publication. A super-tree involving six clades and all structural relationships was established and is now presented for four of the species. The wealth of functional data available for members of the bHLH gene superfamily provides us with the opportunity to use this exhaustive phylogenetic tree to predict potential functions of uncharacterized members of the family. This phylogenetic and genomic analysis of the bHLH gene family has revealed unique elements of the evolution and functional relationships of the different genes in the bHLH gene family.
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Details
- Title
- Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature
- Creators
- Michael K Skinner - Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4236, USAAlan Rawls - School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, USAJeanne Wilson-Rawls - School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, USAEric H Roalson - School of Biological Sciences, Washington State University, Pullman, WA 99164-4236, USA
- Publication Details
- Differentiation (London), Vol.80(1), pp.1-8
- Academic Unit
- Biological Sciences, School of
- Publisher
- Elsevier B.V
- Number of pages
- 8
- Grant note
- NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01ES012974 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Identifiers
- 99900546819601842
- Language
- English
- Resource Type
- Accepted manuscript