Accepted manuscript
Cannabidiol-Δ9-tetrahydrocannabinol interactions on acute pain and locomotor activity
Drug and alcohol dependence, Vol.175, pp.187-197
06/01/2017
Handle:
https://hdl.handle.net/2376/113672
PMCID: PMC5499986
PMID: 28445853
Abstract
•CBD may prolong THC-induced antinociception and hypolocomotion in rats.•CBD-THC interactions on behavior do not appear to be sex-dependent.•CBD alters THC metabolite production to a greater extent in females than males.
Previous studies suggest that cannabidiol (CBD) may potentiate or antagonize Δ9-tetrahydrocannabinol’s (THC) effects. The current study examined sex differences in CBD modulation of THC-induced antinociception, hypolocomotion, and metabolism.
In Experiment 1, CBD (0, 10 or 30mg/kg) was administered 15min before THC (0, 1.8, 3.2, 5.6 or 10mg/kg), and rats were tested for antinociception and locomotion 15–360min post-THC injection. In Experiments 2 and 3, CBD (30mg/kg) was administered 13h or 15min before THC (1.8mg/kg); rats were tested for antinociception and locomotion 30–480min post-THC injection (Experiment 2), or serum samples were taken 30–360min post-THC injection to examine CBD modulation of THC metabolism (Experiment 3).
In Experiment 1, CBD alone produced no antinociceptive effects, while enhancing THC-induced paw pressure but not tail withdrawal antinociception 4–6h post-THC injection. CBD alone increased locomotor activity at 6h post-injection, but enhanced THC-induced hypolocomotion 4–6h post-THC injection, at lower THC doses. There were no sex differences in CBD-THC interactions. In Experiments 2 and 3, CBD did not significantly enhance THC’s effects when CBD was administered 13h or 15min before THC; however, CBD inhibited THC metabolism, and this effect was greater in females than males.
These results suggest that CBD may enhance THC’s antinociceptive and hypolocomotive effects, primarily prolonging THC’s duration of action; however, these effects were small and inconsistent across experiments. CBD inhibition of THC metabolism as well other mechanisms likely contribute to CBD-THC interactions on behavior.
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Details
- Title
- Cannabidiol-Δ9-tetrahydrocannabinol interactions on acute pain and locomotor activity
- Creators
- Stevie C Britch - Department of Psychology, Washington State University, Pullman, WA, 99164-4820, USAJenny L Wiley - RTI International, Research Triangle Park, NC, 27709-2194, USAZhihao Yu - Department of Chemistry, Washington State University, Pullman, WA, 99164-4630, USABrian H Clowers - Department of Chemistry, Washington State University, Pullman, WA, 99164-4630, USARebecca M Craft - Department of Psychology, Washington State University, Pullman, WA, 99164-4820, USA
- Publication Details
- Drug and alcohol dependence, Vol.175, pp.187-197
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Number of pages
- 11
- Grant note
- DA-016644 / National Institutes of Health, National Institute on Drug Abuse (NIH/NIDA); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) 502 / State of Washington Initiative Measure R01DA016644 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission
- Identifiers
- 99900547979101842
- Language
- English
- Resource Type
- Accepted manuscript