Cysteine-activated hydrogen sulfide (H2S) donors

Yu Zhao; Hua Wang; Ming Xian

doi:10.1021/ja1085723

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Cysteine-activated hydrogen sulfide (H2S) donors

Accepted manuscript

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Cysteine-activated hydrogen sulfide (H2S) donors

Yu Zhao, Hua Wang and Ming Xian

Journal of the American Chemical Society, Vol.133(1), pp.15-17

01/12/2011

DOI: https://doi.org/10.1021/ja1085723

Handle:

https://hdl.handle.net/2376/100385

PMCID: PMC3073703

PMID: 21142018

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Abstract

Hydrogen Sulfide - metabolism

Cysteine - metabolism

Kinetics

H(2)S, the newly discovered gasotransmitter, plays important roles in biological systems. However, the research on H(2)S has been hindered by the lack of controllable H(2)S donors that could mimic the slow and continuous H(2)S generation process in vivo. Herein we report a series of cysteine-activated H(2)S donors. Structural modifications of these molecules can regulate the rates of H(2)S generation. These compounds can be useful tools in H(2)S research.

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Details

Title: Cysteine-activated hydrogen sulfide (H2S) donors
Creators: Yu Zhao - Washington State University
Hua Wang
Ming Xian
Publication Details: Journal of the American Chemical Society, Vol.133(1), pp.15-17
Academic Unit: Department of Chemistry
Publisher: Amer Chemical Soc; United States
Number of pages: 3
Grant note: R01 GM088226 / NIGMS NIH HHS R01 GM088226-01A1 / NIGMS NIH HHS R01GM088226 / NIGMS NIH HHS
Identifiers: 99900546789701842
Language: English
Resource Type: Accepted manuscript