Accepted manuscript
Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10‐deficient mice
Molecular nutrition & food research, Vol.57(12), pp.2253-2257
12/2013
Handle:
https://hdl.handle.net/2376/113539
PMID: 23963706
Abstract
Grape seed extract (GSE) is a by‐product of the wine industry, with abundant polyphenolic compounds known for their anti‐inflammatory and anti‐oxidative effects. Using IL10‐deficient mice (IL10KO), here we showed that GSE (1% of dry feed weight) ameliorated inflammatory bowel disease indices, increased colonic goblet cell numbers and decreased myeloperoxidase levels in the large intestine. Concomitantly, GSE supplementation attenuated inflammation, decreased the expression of pore forming tight junction protein claudin2, and increased levels of Lactobacilli and Bacteroides in the gut microbiota of IL10KO mice. In summary, our study shows that GSE has protective roles on inflammatory bowel disease through altering gut inflammation, tight junction protein expression, and gut microbiota composition.
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Details
- Title
- Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10‐deficient mice
- Creators
- Hui Wang - University of WyomingYansong Xue - Washington State University/University of IdahoHanying Zhang - University of WyomingYan Huang - University of WyomingGuan Yang - Washington State University/University of IdahoMin Du - Washington State UniversityMei‐Jun Zhu - Washington State University/University of Idaho
- Publication Details
- Molecular nutrition & food research, Vol.57(12), pp.2253-2257
- Academic Unit
- Department of Pharmaceutical Sciences; Department of Animal Sciences
- Publisher
- Wiley
- Number of pages
- 5
- Grant note
- Washington State University USDA‐AFRI (2009‐65203‐05716; NIHR15HD073864)
- Identifiers
- 99900547925301842
- Language
- English
- Resource Type
- Accepted manuscript