Endocrine disruptors in 2015: Epigenetic transgenerational inheritance

Michael K Skinner

doi:10.1038/nrendo.2015.206

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Endocrine disruptors in 2015: Epigenetic transgenerational inheritance

Accepted manuscript

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Peer reviewed

Endocrine disruptors in 2015: Epigenetic transgenerational inheritance

Michael K Skinner

Nature reviews. Endocrinology, Vol.12(2), pp.68-70

02/2016

DOI: https://doi.org/10.1038/nrendo.2015.206

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https://hdl.handle.net/2376/115693

PMID: 26585656

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Abstract

Gene Expression - drug effects

Germ Cells - drug effects

Hypospadias - genetics

Spermatozoa - metabolism

Mutation - genetics

Spermatozoa - drug effects

Hypospadias - chemically induced

Prenatal Exposure Delayed Effects - genetics

Endocrine Disruptors - pharmacology

Mutation - drug effects

Epigenesis, Genetic - genetics

Epigenesis, Genetic - drug effects

Oxazoles - pharmacology

Diethylhexyl Phthalate - pharmacology

Germ Cells - metabolism

Prenatal Exposure Delayed Effects - chemically induced

RNA, Untranslated - drug effects

Epigenetics

Endocrine disruptors are critical environmental exposures that influence health and can promote epigenetic transgenerational inheritance of disease and abnormal physiology. Advances in 2015 included analyses of the effects of endocrine disruptors on human disease, further examples of endocrine disruptors promoting transgenerational behavioural effects, insights into effects of endocrine disruptors on epigenetic programming of primordial germ cells and the finding that endocrine disruptors can transgenerationally promote genetic mutations.

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Title: Endocrine disruptors in 2015: Epigenetic transgenerational inheritance
Creators: Michael K Skinner - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington 99164-4236, USA
Publication Details: Nature reviews. Endocrinology, Vol.12(2), pp.68-70
Academic Unit: Biological Sciences, School of
Publisher: Springer Nature; England
Number of pages: 3
Grant note: R01 ES012974 / NIEHS NIH HHS
Identifiers: 99900547687001842
Language: English
Resource Type: Accepted manuscript