Accepted manuscript
Environmental epigenomics and disease susceptibility
Nature reviews. Genetics, Vol.8(4), pp.253-262
04/2007
Handle:
https://hdl.handle.net/2376/107736
PMCID: PMC5940010
PMID: 17363974
Abstract
Epidemiological evidence increasingly suggests that environmental exposures early in development have a role in susceptibility to disease in later life. In addition, some of these environmental effects seem to be passed on through subsequent generations. Epigenetic modifications provide a plausible link between the environment and alterations in gene expression that might lead to disease phenotypes. An increasing body of evidence from animal studies supports the role of environmental epigenetics in disease susceptibility. Furthermore, recent studies have demonstrated for the first time that heritable environmentally induced epigenetic modifications underlie reversible transgenerational alterations in phenotype. Methods are now becoming available to investigate the relevance of these phenomena to human disease.
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Details
- Title
- Environmental epigenomics and disease susceptibility
- Creators
- Randy L Jirtle - Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA. jirtle@radonc.duke.eduMichael K Skinner
- Publication Details
- Nature reviews. Genetics, Vol.8(4), pp.253-262
- Academic Unit
- Biological Sciences, School of
- Publisher
- England
- Grant note
- R01 ES012974 / NIEHS NIH HHS
- Identifiers
- 99900546966301842
- Language
- English
- Resource Type
- Accepted manuscript