Accepted manuscript
Environmental signals and transgenerational epigenetics
Epigenomics, Vol.1(1), pp.111-117
10/2009
Handle:
https://hdl.handle.net/2376/116266
PMCID: PMC2886501
PMID: 20563319
Abstract
The ability of an environmental factor or toxicant to promote a phenotype or disease state not only in the individual exposed, but also in subsequent progeny for multiple generations, is termed transgenerational inheritance. The majority of environmental agents do not promote genetic mutations or alterations in DNA sequence, but do have the capacity to alter the epigenome. Although most environmental exposures will influence somatic cells and not allow the transgenerational transmission of a phenotype, the ability of an environmental factor to reprogram the germline epigenome can promote a transgenerational inheritance of phenotypes and disease states. A limited number of critical developmental periods exist when environmental signals can produce a significant epigenetic reprogramming of the germline. In this review, the ability of environmental factors or toxicants to promote epigenetic transgenerational phenotypes is reviewed.
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Details
- Title
- Environmental signals and transgenerational epigenetics
- Creators
- Michael K SkinnerCarlos Guerrero-Bosagna
- Publication Details
- Epigenomics, Vol.1(1), pp.111-117
- Academic Unit
- Biological Sciences, School of
- Publisher
- Future Medicine Ltd
- Number of pages
- 7
- Grant note
- R01 ES012974; R01 ES012974-07; R01 ES012974-05A1 / NIEHS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R01ES012974 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Identifiers
- 99900548166001842
- Language
- English
- Resource Type
- Accepted manuscript