Environmentally induced epigenetic transgenerational inheritance of phenotype and disease

Carlos Guerrero-Bosagna; Michael K Skinner

doi:10.1016/j.mce.2011.10.004

Back

Environmentally induced epigenetic transgenerational inheritance of phenotype and disease

Accepted manuscript

Open access

Peer reviewed

Environmentally induced epigenetic transgenerational inheritance of phenotype and disease

Carlos Guerrero-Bosagna and Michael K Skinner

Molecular and cellular endocrinology, Vol.354(1-2), pp.3-8

05/06/2012

DOI: https://doi.org/10.1016/j.mce.2011.10.004

Handle:

https://hdl.handle.net/2376/114257

PMCID: PMC3312615

PMID: 22020198

Files and links (2)

pdf

Environmentally induced epigenetic transgenerational inheritance of phenotype and disease343.37 kBDownload View

Open Access

url

https://doi.org/10.1016/j.mce.2011.10.004View

Published (Version of record) Open

Abstract

Cell Division - genetics

Disease - genetics

Environmental Pollutants - pharmacology

Environmental Exposure

Endocrine Disruptors - pharmacology

Germ-Line Mutation

Epigenesis, Genetic - drug effects

Epigenetics

Systems Biology

Phenotype

Reproduction

Environmental epigenetics has an important role in regulating phenotype formation or disease etiology. The ability of environmental factors and exposures early in life to alter somatic cell epigenomes and subsequent development is a critical factor in how environment affects biology. Environmental epigenetics provides a molecular mechanism to explain long term effects of environment on the development of altered phenotypes and "emergent" properties, which the "genetic determinism" paradigm cannot. When environmental factors permanently alter the germ line epigenome, then epigenetic transgenerational inheritance of these environmentally altered phenotypes and diseases can occur. This environmental epigenetic transgenerational inheritance of phenotype and disease is reviewed with a systems biology perspective.

Metrics

1 File views/ downloads

12 Record Views

See more details

Details

Title: Environmentally induced epigenetic transgenerational inheritance of phenotype and disease
Creators: Carlos Guerrero-Bosagna - Washington State University, Center for Reproductive Biology
Michael K Skinner
Publication Details: Molecular and cellular endocrinology, Vol.354(1-2), pp.3-8
Academic Unit: Biological Sciences, School of
Publisher: Ireland
Grant note: R01 ES012974-07 / NIEHS NIH HHS R01 ES012974 / NIEHS NIH HHS
Identifiers: 99900547543801842
Language: English
Resource Type: Accepted manuscript