Accepted manuscript
Environmentally induced epigenetic transgenerational inheritance of male infertility
Current opinion in genetics & development, Vol.26, pp.79-88
06/2014
Handle:
https://hdl.handle.net/2376/117579
PMCID: PMC4252707
PMID: 25104619
Abstract
Decreasing male fertility has been observed for the past fifty years. Examples of affected reproductive parameters include decreases in sperm count and sperm quality and increases in testicular cancer, cryptorchidism and hypospadias. Exposures to environmental toxicants during fetal development and early postnatal life have been shown to promote infertility. Environmental exposures inducing epigenetic changes related to male infertility range from life style, occupational exposures, environmental toxicants and nutrition. Exposures during fetal gonadal sex determination have been shown to alter the epigenetic programming of the germline that then can transmit this altered epigenetic information to subsequent generations in the absence of any exposures. This environmentally induced epigenetic transgenerational inheritance of disease will be a component of the etiology of male infertility.
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Details
- Title
- Environmentally induced epigenetic transgenerational inheritance of male infertility
- Creators
- Carlos Guerrero-Bosagna - Avian Behaviourial Genomics and Physiology Group, IFM Biology, Linköping University, Linköping, SwedenMichael K Skinner - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, United States. Electronic address: skinner@wsu.edu
- Publication Details
- Current opinion in genetics & development, Vol.26, pp.79-88
- Academic Unit
- Biological Sciences, School of
- Publisher
- England
- Grant note
- R01 ES012974 / NIEHS NIH HHS
- Identifiers
- 99900548162601842
- Language
- English
- Resource Type
- Accepted manuscript