Environmentally induced epigenetic transgenerational inheritance of disease susceptibility

Eric E Nilsson; Michael K Skinner

doi:10.1016/j.trsl.2014.02.003

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Environmentally induced epigenetic transgenerational inheritance of disease susceptibility

Accepted manuscript

Open access

Peer reviewed

Environmentally induced epigenetic transgenerational inheritance of disease susceptibility

Eric E Nilsson and Michael K Skinner

Translational research : the journal of laboratory and clinical medicine, Vol.165(1), pp.12-17

01/2015

DOI: https://doi.org/10.1016/j.trsl.2014.02.003

Handle:

https://hdl.handle.net/2376/115559

PMCID: PMC4148471

PMID: 24657180

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Abstract

DNA Methylation

Genetic Predisposition to Disease

Disease Susceptibility

Epigenesis, Genetic

Translational Medical Research

Germ-Line Mutation

Environmental Exposure

Epigenetics

Environmental insults, such as exposure to toxicants or nutritional abnormalities, can lead to epigenetic changes that are in turn related to increased susceptibility to disease. The focus of this review is on the transgenerational inheritance of such epigenetic abnormalities (epimutations), and how it is that these inherited epigenetic abnormalities can lead to increased disease susceptibility, even in the absence of continued environmental insult. Observations of environmental toxicant specificity and exposure-specific disease susceptibility are discussed. How epimutations are transmitted across generations and how epigenetic changes in the germline are translated into an increased disease susceptibility in the adult is reviewed with regard to disease etiology.

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Title: Environmentally induced epigenetic transgenerational inheritance of disease susceptibility
Creators: Eric E Nilsson - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Wash
Michael K Skinner - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Wash. Electronic address: skinner@wsu.edu
Publication Details: Translational research : the journal of laboratory and clinical medicine, Vol.165(1), pp.12-17
Academic Unit: Biological Sciences, School of
Publisher: United States
Grant note: R01 ES012974 / NIEHS NIH HHS
Identifiers: 99900548293401842
Language: English
Resource Type: Accepted manuscript