Epigenetic transgenerational actions of endocrine disruptors

Michael K Skinner; Mohan Manikkam; Carlos Guerrero-Bosagna

doi:10.1016/j.reprotox.2010.10.012

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Epigenetic transgenerational actions of endocrine disruptors

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Peer reviewed

Epigenetic transgenerational actions of endocrine disruptors

Michael K Skinner, Mohan Manikkam and Carlos Guerrero-Bosagna

Reproductive toxicology (Elmsford, N.Y.), Vol.31(3), pp.337-343

04/2011

DOI: https://doi.org/10.1016/j.reprotox.2010.10.012

Handle:

https://hdl.handle.net/2376/105484

PMCID: PMC3068236

PMID: 21055462

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Abstract

Abnormalities, Drug-Induced - epidemiology

Prenatal Exposure Delayed Effects - epidemiology

Sex Differentiation - drug effects

Prenatal Exposure Delayed Effects - etiology

Endocrine Disruptors - toxicity

Environmental Exposure - adverse effects

Reproduction - drug effects

Abnormalities, Drug-Induced - etiology

Epigenesis, Genetic - drug effects

Environmental Pollutants - toxicity

Disease Models, Animal

Pregnancy

Environmental factors have a significant impact on biology. Therefore, environmental toxicants through similar mechanisms can modulate biological systems to influence physiology and promote disease states. The majority of environmental toxicants do not have the capacity to modulate DNA sequence, but can alter the epigenome. In the event an environmental toxicant such as an endocrine disruptor modifies the epigenome of a somatic cell, this may promote disease in the individual exposed, but not be transmitted to the next generation. In the event a toxicant modifies the epigenome of the germ line permanently, then the disease promoted can become transgenerationaly transmitted to subsequent progeny. The current review focuses on the ability of environmental factors such as endocrine disruptors to promote transgenerational phenotypes.

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Title: Epigenetic transgenerational actions of endocrine disruptors
Creators: Michael K Skinner - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164-4236, United States. skinner@wsu.edu
Mohan Manikkam
Carlos Guerrero-Bosagna
Publication Details: Reproductive toxicology (Elmsford, N.Y.), Vol.31(3), pp.337-343
Academic Unit: Biological Sciences, School of
Publisher: United States
Grant note: R01 ES012974-07 / NIEHS NIH HHS R01 ES012974 / NIEHS NIH HHS
Identifiers: 99900546602901842
Language: English
Resource Type: Accepted manuscript