Accepted manuscript
Epigenetic transgenerational actions of vinclozolin on the development of disease and cancer
Critical reviews in oncogenesis, Vol.13(1), pp.75-82
08/2007
Handle:
https://hdl.handle.net/2376/105838
PMID: 17956218
Abstract
Exposure to an environmental endocrine disruptor (e.g., vinclozolin) during embryonic gonadal sex determination appears to alter the male germ line epigenome and subsequently promotes transgenerational adult onset disease. The epigenetic mechanism involves the induction of new imprinted-like genes/DNA sequences in the germ line that appear to transmit disease phenotypes. The disease phenotypes include testis abnormalities, prostate disease, kidney disease, immune abnormalities, and tumor development. This epigenetic transgenerational disease mechanism provides a unique perspective from which to view inheritable adult onset disease states, such as cancer, and ultimately offers new insights into novel diagnostic and therapeutic strategies.
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Details
- Title
- Epigenetic transgenerational actions of vinclozolin on the development of disease and cancer
- Creators
- Michael K Skinner - Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman WA 99164-4231, USA. skinner@mail.wsu.eduMatthew D Anway
- Publication Details
- Critical reviews in oncogenesis, Vol.13(1), pp.75-82
- Academic Unit
- Biological Sciences, School of
- Publisher
- United States
- Grant note
- R01 ES012974 / NIEHS NIH HHS
- Identifiers
- 99900546940301842
- Language
- English
- Resource Type
- Accepted manuscript