Epigenetic transgenerational effects of endocrine disruptors on male reproduction

Carlos M Guerrero-Bosagna; Michael K Skinner

doi:10.1055/s-0029-1237428

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Epigenetic transgenerational effects of endocrine disruptors on male reproduction

Accepted manuscript

Open access

Peer reviewed

Epigenetic transgenerational effects of endocrine disruptors on male reproduction

Carlos M Guerrero-Bosagna and Michael K Skinner

Seminars in reproductive medicine, Vol.27(5), pp.403-408

09/2009

DOI: https://doi.org/10.1055/s-0029-1237428

Handle:

https://hdl.handle.net/2376/107294

PMCID: PMC3562087

PMID: 19711250

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Abstract

Genetic Predisposition to Disease

Inheritance Patterns - drug effects

Fetal Development - drug effects

Gene Expression Regulation, Developmental - drug effects

Reproduction - genetics

Terminology as Topic

Endocrine Disruptors - toxicity

Reproduction - drug effects

Oxazoles - toxicity

Genitalia, Male - embryology

Genitalia, Male - drug effects

Epigenesis, Genetic - drug effects

Phenotype

Endocrine-disrupting chemicals generally function as steroid receptor signaling antagonists or agonists that influence development to promote adult-onset disease. Exposure to the endocrine disruptors during the initiation of male reproductive tract development interferes with the normal hormonal signaling and formation of male reproductive organs. In particular, exposure to the endocrine disruptor vinclozolin promotes transgenerational transmission of adult-onset disease states such as male infertility, increased frequencies of tumors, prostate disease, kidney diseases, and immune abnormalities that develop as males age. An epigenetic change in the germ line would be involved in the transgenerational transmission of these induced phenotypes. Nevertheless, other studies have also reported transgenerational transmission of induced epigenetic changes, without altering the germ line. Here we propose a nomenclature to help clarify both cases of transgenerational epigenetic transmission. An intrinsic epigenetic transgenerational process would require a germ-line involvement, a permanent alteration in the germ cell epigenome, and only one exposure to the environmental factor. An extrinsic epigenetic transgenerational process would involve an epigenetic alteration in a somatic tissue and require exposure at each generation to maintain the transgenerational phenotype.

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Title: Epigenetic transgenerational effects of endocrine disruptors on male reproduction
Creators: Carlos M Guerrero-Bosagna - Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4231, USA
Michael K Skinner
Publication Details: Seminars in reproductive medicine, Vol.27(5), pp.403-408
Academic Unit: Biological Sciences, School of
Publisher: Thieme Medical Publishers; United States
Number of pages: 6
Grant note: R01 ES012974-07 / NIEHS NIH HHS R01 ES012974 / NIEHS NIH HHS
Identifiers: 99900547234101842
Language: English
Resource Type: Accepted manuscript