Accepted manuscript
Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries
International journal of cancer, Vol.136(5), pp.1125-1139
03/01/2015
Handle:
https://hdl.handle.net/2376/106141
PMCID: PMC4531373
PMID: 24996155
Abstract
Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR = 2.50; 95% CI = 2.02 – 3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR = 1.61; 95% CI = 1.13 – 2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels.
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- Title
- Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries
- Creators
- David I Conway - Glasgow Dental School, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United KingdomPhilip Lazarus - Washington State University College of Pharmacy, Spokane, WADarren R Brenner - International Agency for Research on Cancer, Lyon, FranceAlex D McMahon - Glasgow Dental School, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United KingdomLorna M.D Macpherson - Glasgow Dental School, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United KingdomAntonio Agudo - Unit of Nutrition, Environment and Cancer Epidemiology Research Program, Catalan Institute of Oncology-ICO, L'Hospitalet de Llobregat, Barcelona, SpainWolfgang Ahrens - BIPS-Institute for Epidemiology and Prevention Research, Bremen, GermanyCristina Bosetti - Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri,”, Milan, ItalyHermann Brenner - German Cancer Research Center, Heidelberg, GermanyXavier Castellsague - Institut Catala d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Barcelona, Catalonia, SpainChu Chen - Fred Hutchinson Cancer Research Center, Seattle, WAMaria Paula Curado - International Prevention Research Institute, Lyon, FranceOtávio A Curioni - Hospital Heliopolis, Sao Paulo, BrazilLuigino Dal Maso - Epidemiology and Biostatistics Unit, Centro di Riferimento Oncologico IRCCS, Aviano, ItalyAlexander W Daudt - Hospital de Clinicas de Porto Alegre, Porto Alegre, BrazilJosé F de Gois Filho - Instituto do Cancer Arnaldo Viera de Carvalho, Sao Paulo, BrazilGypsyamber D'Souza - Johns Hopkins Bloomberg School of Public Health, Baltimore, MDValeria Edefonti - Department of Clinical Sciences and Community Health, University of Milan, ItalyEleonora Fabianova - Regional Authority of Public Health, Banska Bystrica, SlovakiaLeticia Fernandez - Institute of Oncology and Radiobiology, Havana, CubaSilvia Franceschi - International Agency for Research on Cancer, Lyon, FranceMaura Gillison - The Ohio State University, Comprehensive Cancer Center, Columbus, OHRichard B Hayes - Division of Epidemiology, New York University, School of Medicine, NYClaire M Healy - Trinity College School of Dental Science, Dublin, IrelandRolando Herrero - Prevention and Implementation Group, International Agency for Research on Cancer, Lyon, FranceIvana Holcatova - First Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University, Prague, Czech RepublicVijayvel Jayaprakash - Roswell Park Cancer Institute, Buffalo, NYKarl Kelsey - Brown University, Providence, Rhode IslandKristina Kjaerheim - Cancer Registry of Norway, Oslo, NorwaySergio Koifman - Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, BrazilCarlo La Vecchia - Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri,”, Milan, ItalyPagona Lagiou - University of Athens School of Medicine, Athens, GreeceFabio Levi - Institut de Médecine Sociale et Préventive (IUMSP), Centre Hospitalier Universitaire Vaudois et Université de Lausanne, Lausanne, SwitzerlandJolanta Lissowska - Department of Cancer Epidemiology and Prevention, The M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, PolandDaniele Luce - Inserm, Center for Research in Epidemiology and Population Health (CESP), U1018, Occupational and Environmental Determinants of Health, Villejuif, FranceTatiana V Macfarlane - University of Aberdeen Dental School, Aberdeen, United KingdomDana Mates - National Institute of Public Health, Bucharest, RomaniaElena Matos - Institute of Oncology Angel H. Roffo, University of Buenos Aires, ArgentinaMichael McClean - Boston University School of Public Health, Boston, MAAna M Menezes - Universidade Federal de Pelotas, BrazilGwenn Menvielle - Inserm, Center for Research in Epidemiology and Population Health (CESP), U1018, Occupational and Environmental Determinants of Health, Villejuif, FranceFranco Merletti - Department of Medical Sciences, University of Turin, ItalyHal Morgenstern - Departments of Epidemiology and Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MIKirsten Moysich - Roswell Park Cancer Institute, Buffalo, NYHeiko Müller - Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri,”, Milan, ItalyJoshua Muscat - Penn State College of Medicine, Hershey, PAAndrew F Olshan - Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NCMark P Purdue - National Cancer Institute, Bethesda, MDHeribert Ramroth - Institute of Public Health, University of Heidelberg, GermanyLorenzo Richiardi - Department of Medical Sciences, University of Turin, ItalyPeter Rudnai - National Institute of Environmental Health, Budapest, HungaryStimson Schantz - New York Eye and Ear Infirmary, NYStephen M Schwartz - Fred Hutchinson Cancer Research Center, Seattle, WAOxana Shangina - Cancer Research Centre, Moscow, RussiaLorenzo Simonato - Department of Molecular Medicine, Laboratory of Public Health and Population Studies, University of Padova, ItalyElaine Smith - College of Public Health, University of IowaIsabelle Stucker - Inserm, Center for Research in Epidemiology and Population Health (CESP), U1018, Occupational and Environmental Determinants of Health, Villejuif, FranceErich M Sturgis - UT-M.D. Anderson Cancer Center, Houston, TXNeonila Szeszenia-Dabrowska - Institute of Occupational Medicine, Lodz, PolandRenato Talamini - Epidemiology and Biostatistics Unit, Centro di Riferimento Oncologico IRCCS, Aviano, ItalyPeter Thomson - University of Newcastle, United KingdomThomas L Vaughan - Fred Hutchinson Cancer Research Center, Seattle, WAQingyi Wei - UT-M.D. Anderson Cancer Center, Houston, TXDeborah M Winn - National Cancer Institute, National Institutes of Health, Bethesda, MDVictor Wunsch-Filho - Department of Epidemiology, Faculdade de Saude Publica, Universidade de Sao Paulo, BrazilGuo-Pei Yu - New York Medical College, Valhalla, NYZuo-Feng Zhang - UCLA School of Public Health, Los Angeles, CATongzhang Zheng - Yale University, New Heaven, CTAriana Znaor - Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, CroatiaPaolo Boffetta - International Prevention Research Institute, Lyon, FranceShu-Chun Chuang - Division of Health Policy Translation, Institute of Population Health Sciences, National Health Research Institutes, Miaoli, TaiwanMarianoosh Ghodrat - University of Utah School of Medicine, Salt Lake City, UTYuan-Chin Amy Lee - University of Utah School of Medicine, Salt Lake City, UTMia Hashibe - University of Utah School of Medicine, Salt Lake City, UTPaul Brennan - International Agency for Research on Cancer, Lyon, France
- Publication Details
- International journal of cancer, Vol.136(5), pp.1125-1139
- Academic Unit
- Department of Pharmaceutical Sciences
- Publisher
- Wiley
- Number of pages
- 15
- Grant note
- International Agency for Research on Cancer, Lyon, France Visiting Scientist Award R03DE016611 / NIDCR; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) UICC Yamagiwa-Yoshida Memorial International Cancer Study PRIN 2009 X8YCBN / Italian Ministry of Research; Ministry of Education, Universities and Research (MIUR) Swiss Research against Cancer/Oncosuisse, Switzerland R03CA113157 / NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 10068 / Italian Association for Research on Cancer (AIRC); Fondazione AIRC per la ricerca sul cancro T32CA009142 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Swiss League against Cancer INHANCE Pooled Data Coordination
- Identifiers
- 99900546863701842
- Language
- English
- Resource Type
- Accepted manuscript