Accepted manuscript
Fetal muscle development, mesenchymal multipotent cell differentiation and associated signaling pathways
Journal of animal science, Vol.89(2), pp.583-590
02/2011
Handle:
https://hdl.handle.net/2376/104850
PMCID: PMC4100697
PMID: 20852073
Abstract
Meat animals are raised for their carcasses, and carcasses are composed from muscle, fat and bone. Enhancing muscle growth and reducing fat accumulation improve the efficiency of animal production. Fetal stage is crucial for skeletal muscle development. Due to extensive efforts to increase lean growth, marbling (intramuscular fat) is reducing in beef, pork and chicken breast, which impairs the eating quality of meat. Because fat is the major contributor to meat flavor, the presence of intramuscular fat is indispensible for the high eating quality of meat. However, up to now, our understanding of adipogenesis (formation of fat cells) in skeletal muscle is limited. Adipocyte differentiation in skeletal muscle initiates from mesenchymal multipotent cells, which are abundant in skeletal muscle at early developmental stages. In this review, the known cellular mechanisms regulating adipogenesis from multipotent cells are summarized, which include hedgehog, Wingless and Int (Wnt)/α-catenin, and bone morphogenesis protein (BMP) mediated signaling pathways, as well as AMP-activated protein kinase. Promoting adipogenesis inside skeletal muscle will dramatically increase intramuscular fat, improving the quality of meat.
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Details
- Title
- Fetal muscle development, mesenchymal multipotent cell differentiation and associated signaling pathways
- Creators
- Min DuJun X ZhaoXu YanYan HuangLander V NicodemusMei J Zhu
- Publication Details
- Journal of animal science, Vol.89(2), pp.583-590
- Academic Unit
- Department of Animal Sciences
- Number of pages
- 8
- Identifiers
- 99900546568701842
- Language
- English
- Resource Type
- Accepted manuscript