Accepted manuscript
Gonadal hormone modulation of mu, kappa, and delta opioid antinociception in male and female rats
The journal of pain, Vol.6(4), pp.261-274
2005
Handle:
https://hdl.handle.net/2376/114648
PMCID: PMC1420268
PMID: 15820914
Abstract
Previous studies suggest that sex differences in morphine antinociception in rodents might be attributed to the activational effects of gonadal hormones. The present study determined whether hormonal modulation of opioid antinociception in adult rats extends to opioids other than the prototypic mu agonist morphine. Male and female rats were sham-gonadectomized (sham-GDX) or gonadectomized (GDX) and replaced with no hormone, estradiol (E2, females), progesterone (P4, females), E2+P4 (females), or testosterone (males). Approximately 28 days later, nociception was evaluated on the 50°C hot plate and warm water tail withdrawal tests before and after subcutaneous administration of hydromorphone, buprenorphine, U50,488, or SNC 80. In sham-GDX (gonadally intact) rats, the mu agonists and U50,488 were less effective in females than in males in at least one nociceptive test, and the delta agonist SNC 80 was less effective in males than in females. In males, gonadectomy tended to decrease, and testosterone tended to increase antinociception produced by 3 of the 4 agonists. In females, gonadectomy and hormone treatment had more variable effects, although E2 tended to decrease mu opioid antinociception. The present results suggest that activational effects of gonadal hormones are relatively modest and somewhat inconsistent on antinociception produced by various opioid agonists in the adult rat.
This study demonstrates that reproductive hormones such as testosterone in males and estradiol in females do not consistently modulate sensitivity to the analgesic effects of opioids in the adult organism.
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Details
- Title
- Gonadal hormone modulation of mu, kappa, and delta opioid antinociception in male and female rats
- Creators
- Erin C Stoffel - Department of Psychology, Washington State University, Pullman, WashingtonCatherine M Ulibarri - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WashingtonJohn E Folk - Laboratory of Medicinal Chemistry, NIDDK, NIH, Bethesda, MarylandKenner C Rice - Laboratory of Medicinal Chemistry, NIDDK, NIH, Bethesda, MarylandRebecca M Craft - Department of Psychology, Washington State University, Pullman, Washington
- Publication Details
- The journal of pain, Vol.6(4), pp.261-274
- Academic Unit
- Psychology, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900548309001842
- Language
- English
- Resource Type
- Accepted manuscript