Accepted manuscript
History of Diabetes and Risk of Head and Neck Cancer: A Pooled Analysis from the International Head and Neck Cancer Epidemiology Consortium
Cancer epidemiology, biomarkers & prevention, Vol.21(2), pp.294-304
2012
Handle:
https://hdl.handle.net/2376/112287
PMCID: PMC3275674
PMID: 22144496
Abstract
Background: A history of diabetes is associated with an increased risk of several types of cancers. Whether diabetes is a risk factor for head and neck cancer (HNC) has received little attention.
Methods: We pooled data from 12 case control studies including 6,448 cases and 13,747 controls, and estimated OR and 95% CI for the associations between diabetes and HNC, adjusted for age, education level, sex, race/ethnicity, study center, cigarette smoking, alcohol use, and body mass index.
Results: We observed a weak association between diabetes and the incidence of HNC overall (OR, 1.09; 95% CI: 0.95-1.24). However, we observed a modest association among never smokers (OR, 1.59; 95% CI: 1.22-2.07), and no association among ever smokers (OR, 0.96; 95% CI: 0.83-1.11); likelihood ratio test for interaction P = 0.001
Conclusion: A history of diabetes was weakly associated with HNC overall, but we observed evidence of effect modification by smoking status, with a positive association among those who never smoked cigarettes.
Impact: This study suggests that glucose metabolism abnormalities may be a HNC risk factor in subgroups of the population. Prospective studies incorporating biomarkers are needed to improve our understanding of the relationship between diabetes and HNC risk, possibly providing new strategies in the prevention of HNC. Cancer Epidemiol Biomarkers Prey; 21(2); 294-304. (C)2011 AACR.
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Details
- Title
- History of Diabetes and Risk of Head and Neck Cancer: A Pooled Analysis from the International Head and Neck Cancer Epidemiology Consortium
- Creators
- Marni STOTT-MILLER - Fred Hutchinson Cancer Research Center, United StatesCHU CHU CHEN - Fred Hutchinson Cancer Research Center, United StatesFabio LEVI - Institut de Médecine Sociale et Preventive, Université de Lausanne, Lausanne, SwitzerlandKeitaro MATSUO - Aichi Cancer Center Research Institute, Nagoya, JapanHal MORGENSTERN - Department of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United StatesHeiko MÜLLER - German Cancer Research Center, Heidelberg, GermanyJoshua MUSCAT - Penn State College of Medicine, Hershey, Pennsylvania, United StatesAndrew F OLSHAN - University of North Carolina School of Public Health, Chapel Hill, North Carolina, United StatesMark P PURDUE - National Cancer Institute, Bethesda, Maryland, United StatesDiego SERRAINO - Centro di Riferimento Oncologico, Aviano (PN), United StatesThomas L VAUGHAN - Fred Hutchinson Cancer Research Center, United StatesZuo-Feng ZHANG - University of California, Los Angeles, School of Public Health, Los Angeles, California, United StatesShu-Chun CHUANG - School of Public Health, Imperial College London, London, United KingdomPaolo BOFFETTA - International Prevention Research Institute, Lyon, FranceMia HASHIBE - Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, Utah, United StatesStephen M SCHWARTZ - Fred Hutchinson Cancer Research Center, United StatesYuan-Chin AMY LEE - Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, Utah, United StatesStefania BOCCIA - Institute of Hygiene, Universita' Cattolica del Sacro Cuore, Rome, ItalyHermann BRENNER - German Cancer Research Center, Heidelberg, GermanyGabriela CADONI - Institute of Hygiene, Universita' Cattolica del Sacro Cuore, Rome, ItalyLuigino DAL MASO - Centro di Riferimento Oncologico, Aviano (PN), United StatesCarlo LA VECCHIA - Istituto di Ricerche Farmacologiche Mario Negri and University of Milan, Milan, ItalyPhilip LAZARUS - Penn State College of Medicine, Hershey, Pennsylvania, United States
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.21(2), pp.294-304
- Academic Unit
- Department of Pharmaceutical Sciences
- Publisher
- American Association for Cancer Research; Philadelphia, PA
- Number of pages
- 11
- Grant note
- AIRC (Italian Agency for Research on Cancer); Fondazione AIRC per la ricerca sul cancro P30ES010126 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) 17015052 / Grants-in-Aid for Scientific Research; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT); Japan Society for the Promotion of Science; Grants-in-Aid for Scientific Research (KAKENHI) Italian League Against Cancer and Italian Ministry of Research UCLA Jonsson Comprehensive Cancer Center Swiss League against Cancer Italian Association for Research on Cancer (AIRC); Fondazione AIRC per la ricerca sul cancro Ministry of Science, Research and Arts Baden-Wrttemberg; Japan 17015052 / Ministry of Education, Science, Sports, Culture and Technology of Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) KFS-700; OCS-1633 / Swiss Research against Cancer/Oncosuisse
- Identifiers
- 99900547311201842
- Language
- English
- Resource Type
- Accepted manuscript