Accepted manuscript
Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations
Reproductive toxicology (Elmsford, N.Y.), Vol.36, pp.104-116
04/2013
Handle:
https://hdl.handle.net/2376/115956
PMCID: PMC3587983
PMID: 23453003
Abstract
First observation that a hydrocarbon mixture (jet fuel JP-8) promotes epigenetic transgenerational inheritance of disease. ► Ancestral environmental exposures promoted transgenerational sperm epimutations. ► Suggestion ancestral hydrocarbon exposures may be part of the etiology of adult onset disease and obesity. ► Provides additional support for the ability of environmental toxicants to promote epigenetic transgenerational inheritance of disease.
Environmental compounds have been shown to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a hydrocarbon mixture involving jet fuel (JP-8) promotes epigenetic transgenerational inheritance of disease. Gestating F0 generation female rats were transiently exposed during the fetal gonadal development period. The direct exposure F1 generation had an increased incidence of kidney abnormalities in both females and males, prostate and pubertal abnormalities in males, and primordial follicle loss and polycystic ovarian disease in females. The first transgenerational generation is the F3 generation, and the jet fuel lineage had an increased incidence of primordial follicle loss and polycystic ovarian disease in females, and obesity in both females and males. Analysis of the jet fuel lineage F3 generation sperm epigenome identified 33 differential DNA methylation regions, termed epimutations. Observations demonstrate hydrocarbons can promote epigenetic transgenerational inheritance of disease and sperm epimutations, potential biomarkers for ancestral exposures.
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Details
- Title
- Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations
- Creators
- Rebecca TraceyMohan ManikkamCarlos Guerrero-BosagnaMichael K Skinner
- Publication Details
- Reproductive toxicology (Elmsford, N.Y.), Vol.36, pp.104-116
- Academic Unit
- Biological Sciences, School of
- Publisher
- Elsevier Inc
- Number of pages
- 13
- Grant note
- DOD; United States Department of Defense NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01ES012974 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Identifiers
- 99900547649701842
- Language
- English
- Resource Type
- Accepted manuscript