Accepted manuscript
International Lung Cancer Consortium: Pooled Analysis of Sequence Variants in DNA Repair and Cell Cycle Pathways
Cancer epidemiology, biomarkers & prevention, Vol.17(11), pp.3081-3089
11/2008
Handle:
https://hdl.handle.net/2376/100328
PMCID: PMC2756735
PMID: 18990748
Abstract
Background: The International Lung Cancer Consortium was established in 2004. To clarify the role of DNA repair genes in lung cancer susceptibility, we conducted a pooled analysis of genetic variants in DNA repair pathways, whose associations have been investigated by at least 3 individual studies.
Methods: Data from 14 studies were pooled for 18 sequence variants in 12 DNA repair genes, including APEX1, OGG1, XRCC1, XRCC2, XRCC3, ERCC1, XPD, XPF, XPG, XPA, MGMT, and TP53. The total number of subjects included in the analysis for each variant ranged from 2,073 to 13,955 subjects.
Results: Four of the variants were found to be weakly associated with lung cancer risk with borderline significance: these were XRCC3 T241M [heterozygote odds ratio (OR), 0.89; 95% confidence interval (95% CI), 0.79-0.99 and homozygote OR, 0.84; 95% CI, 0.71-1.00] based on 3,467 cases and 5,021 controls from 8 studies, XPD K751Q (heterozygote OR, 0.99; 95% CI, 0.89-1.10 and homozygote OR, 1.19; 95% CI, 1.02-1.39) based on 6,463 cases and 6,603 controls from 9 studies, and TP53 R72P (heterozygote OR, 1.14; 95% CI, 1.00-1.29 and homozygote OR, 1.20; 95% CI, 1.02-1.42) based on 3,610 cases and 5,293 controls from 6 studies. OGG1 S326C homozygote was suggested to be associated with lung cancer risk in Caucasians (homozygote OR, 1.34; 95% CI, 1.01-1.79) based on 2,569 cases and 4,178 controls from 4 studies but not in Asians. The other 14 variants did not exhibit main effects on lung cancer risk.
Discussion: In addition to data pooling, future priorities of International Lung Cancer Consortium include coordinated genotyping and multistage validation for ongoing genome-wide association studies.
Metrics
21 Record Views
Details
- Title
- International Lung Cancer Consortium: Pooled Analysis of Sequence Variants in DNA Repair and Cell Cycle Pathways
- Creators
- Rayjean J Hung - IARC, Lyon, FrancePhilip Lazarus - Penn State College of Medicine, Hershey, PennsylvaniaDavid C Christiani - Harvard University, Boston, MassachusettsAngela Risch - German Cancer Research Center, Heidelberg, GermanyOdilia Popanda - German Cancer Research Center, Heidelberg, GermanyAage Haugen - National Institute of Occupational Health, Oslo, NorwayShan Zienolddiny - National Institute of Occupational Health, Oslo, NorwaySimone Benhamou - INSERM U794, Fondation Jean Dausset CEPH, Paris, FranceChristine Bouchardy - Cancer Registry, Geneva, SwitzerlandQing Lan - National Cancer Institute, RockvilleMargaret R Spitz - The University of Texas M. D. Anderson Cancer Center, Houston, TexasH.-Erich Wichmann - GSF-National Research Center for Environment and Health, Neuherberg, GermanyLoic LeMarchand - University of Hawaii, Hawaii, HonoluluPaolo Vineis - Imperial College, London, United KingdomGiuseppe Matullo - University of Turin, Turin, ItalyChikako Kiyohara - Kyushu University, Fukuoka, JapanZuo-Feng Zhang - University of California at Los Angeles, Los Angeles, CaliforniaBenhnaz Pezeshki - University of California at Los Angeles, Los Angeles, CaliforniaCurtis Harris - National Cancer Institute, RockvilleLeah Mechanic - National Cancer Institute, RockvilleAdeline Seow - National University of Singapore, Singapore, SingaporeDaniel P.K Ng - National University of Singapore, Singapore, SingaporeNeonila Szeszenia-Dabrowska - Department of Epidemiology, Institute of Occupational Medicine, Lodz, PolandDavid Zaridze - Institute of Carcinogenesis, Cancer Research Centre, Moscow, RussiaJolanta Lissowska - Department of Cancer Epidemiology and Prevention, The M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, PolandPeter Rudnai - National Institute of Environmental Health, Fodor József National Center for Public Health, Budapest, HungaryEleonora Fabianova - Regional Authority of Public Health, Banská Bystrica, SlovakiaDana Mates - Institute of Public Health, Bucharest, RomaniaLenka Foretova - Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech RepublicVladimir Janout - Department of Preventive Medicine, Faculty of Medicine, Palacky University, Olomouc, Czech RepublicVladimir Bencko - Charles University of Prague, First Faculty of Medicine, Institute of Hygiene and Epidemiology, Prague, Czech RepublicNeil Caporaso - National Cancer Institute, RockvilleChu Chen - Fred Hutchinson Cancer Research Center, Seattle, WashingtonEric J Duell - IARC, Lyon, FranceGary Goodman - Fred Hutchinson Cancer Research Center, Seattle, WashingtonJohn K Field - Roy Castle Lung Cancer Research Programme, Cancer Research Centre, The University of Liverpool, Liverpool, United KingdomRichard S Houlston - Section of Cancer Genetics, Institute of Cancer Research, Sutton, United KingdomYun-Chul Hong - Seoul National University College of Medicine, Seoul, KoreaMaria Teresa Landi - National Cancer Institute, RockvilleJoshua Muscat - Penn State College of Medicine, Hershey, PennsylvaniaJohn McLaughlin - Cancer Care Ontario, Toronto, Ontario, CanadaAnn G Schwartz - Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MichiganHongbing Shen - Nanjing Medical University School of Public Health, Nanjing, People’s Republic of ChinaIsabelle Stucker - INSERM U754 and UMR-S754, IFR69, Villejuif, FranceKazuo Tajima - Aichi Cancer Center Research Institute, Aichi, JapanKeitaro Matsuo - Aichi Cancer Center Research Institute, Aichi, JapanMichael Thun - American Cancer Society, Atlanta, GeorgiaPing Yang - Mayo Clinic Cancer Center, Rochester, MinnesotaJohn Wiencke - University of California at San Francisco, San Francisco, California andAngeline S Andrew - Dartmouth Medical School, Lebanon, New HampshireStephanie Monnier - IARC, Lyon, FrancePaolo Boffetta - IARC, Lyon, FrancePaul Brennan - IARC, Lyon, France
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.17(11), pp.3081-3089
- Academic Unit
- Department of Pharmaceutical Sciences
- Identifiers
- 99900546532701842
- Language
- English
- Resource Type
- Accepted manuscript