Accepted manuscript
Optofluidic sensing from inkjet-printed droplets: the enormous enhancement by evaporation-induced spontaneous flow on photonic crystal biosilica
Nanoscale, Vol.8(39), pp.17285-17294
10/06/2016
Handle:
https://hdl.handle.net/2376/108422
PMCID: PMC5076880
PMID: 27714122
Abstract
Novel transducers for detecting an ultra-small volume of an analyte solution play pivotal roles in many applications such as chemical analysis, environmental protection and biomedical diagnosis. Recent advances in optofluidics offer tremendous opportunities for analyzing miniature amounts of samples with high detection sensitivity. In this work, we demonstrate enormous enhancement factors (10
-10
) of the detection limit for optofluidic analysis from inkjet-printed droplets by evaporation-induced spontaneous flow on photonic crystal biosilica when compared with conventional surface-enhanced Raman scattering (SERS) sensing using the pipette dispensing technology. Our computational fluid dynamics simulation has shown a strong recirculation flow inside the 100 picoliter droplet during the evaporation process due to the thermal Marangoni effect. The combination of the evaporation-induced spontaneous flow in micron-sized droplets and the highly hydrophilic photonic crystal biosilica is capable of providing a strong convection flow to combat the reverse diffusion force, resulting in a higher concentration of the analyte molecules at the diatom surface. In the meanwhile, high density hot-spots provided by the strongly coupled plasmonic nanoparticles with photonic crystal biosilica under a 1.5 μm laser spot are verified by finite-difference time domain simulation, which is crucial for SERS sensing. Using a drop-on-demand inkjet device to dispense multiple 100 picoliter analyte droplets with pinpoint accuracy, we achieved the single molecule detection of Rhodamine 6G and label-free sensing of 4.5 × 10
g trinitrotoluene from only 200 nanoliter solution.
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Details
- Title
- Optofluidic sensing from inkjet-printed droplets: the enormous enhancement by evaporation-induced spontaneous flow on photonic crystal biosilica
- Creators
- Xianming Kong - School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR 97331, USA. wang@eecs.oregonstate.eduYuting Xi - School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR 97331, USA. wang@eecs.oregonstate.eduPaul LeDuff - School of Chemical, Biological & Environmental Engineering, Oregon State University, Corvallis, OR 97331, USAErwen Li - School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR 97331, USA. wang@eecs.oregonstate.eduYe Liu - School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR 97331, USA. wang@eecs.oregonstate.eduLi-Jing Cheng - School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR 97331, USA. wang@eecs.oregonstate.eduGregory L Rorrer - School of Chemical, Biological & Environmental Engineering, Oregon State University, Corvallis, OR 97331, USAHua Tan - School of Engineering and Computer Science, Washington State University-Vancouver, Vancouver, WA 98686, USA. hua.tan@wsu.eduAlan X Wang - School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR 97331, USA. wang@eecs.oregonstate.edu
- Publication Details
- Nanoscale, Vol.8(39), pp.17285-17294
- Academic Unit
- School of Engineering and Computer Science (VANC)
- Publisher
- England
- Grant note
- R03 EB018893 / NIBIB NIH HHS R42 ES024023 / NIEHS NIH HHS
- Identifiers
- 99900547004301842
- Language
- English
- Resource Type
- Accepted manuscript