Accepted manuscript
Reductive Ligation Mediated One-Step Disulfide Formation of S-Nitrosothiols
Organic letters, Vol.12(18), pp.4208-4211
09/17/2010
Handle:
https://hdl.handle.net/2376/109676
PMCID: PMC2943486
PMID: 20731371
Abstract
A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.
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Details
- Title
- Reductive Ligation Mediated One-Step Disulfide Formation of S-Nitrosothiols
- Creators
- Jiming Zhang - Department of Chemistry, Washington State University, Pullman, WA 99164Sheng Li - Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC 27710Dehui Zhang - Department of Chemistry, Washington State University, Pullman, WA 99164Hua Wang - Department of Chemistry, Washington State University, Pullman, WA 99164A. Richard Whorton - Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC 27710Ming Xian - Department of Chemistry, Washington State University, Pullman, WA 99164
- Publication Details
- Organic letters, Vol.12(18), pp.4208-4211
- Academic Unit
- Department of Chemistry
- Number of pages
- 4
- Identifiers
- 99900547149201842
- Language
- English
- Resource Type
- Accepted manuscript