Accepted manuscript
The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions
Science (American Association for the Advancement of Science), Vol.318(5848), pp.245-250
10/12/2007
Handle:
https://hdl.handle.net/2376/106169
PMCID: PMC2875087
PMID: 17932292
Abstract
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the ∼120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.
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- Title
- The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions
- Creators
- Sanja Roje - Institute of Biological Chemistry, Washington State University, Pullman, WA 99164, USASabeeha S Merchant - Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USASimon E Prochnik - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAOlivier Vallon - CNRS, UMR 7141, CNRS/Université Paris 6, Institut de Biologie Physico-Chimique, 75005 Paris, FranceElizabeth H Harris - Department of Biology, Duke University, Durham, North Carolina 27708, USASteven J Karpowicz - Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USAGeorge B Witman - Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USAAstrid Terry - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAAsaf Salamov - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USALillian K Fritz-Laylin - Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA94720, USALaurence Maréchal-Drouard - Institut de Biologie Moléculaire des Plantes, CNRS, 67084 Strasbourg Cedex, FranceWallace F Marshall - Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94143, USALiang-Hu Qu - University of California, Los AngelesDavid R Nelson - Department of Molecular Sciences and Center of Excellence in Genomics and Bioinformatics, University of Tennessee, Memphis, TN 38163, USAAnton A Sanderfoot - Department of Plant Biology, University of Minnesota, St. Paul MN 55108, USAMartin H Spalding - Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA 50011, USAVladimir V Kapitonov - Genetic Information Research Institute, Mountain View, CA 94043, USAQinghu Ren - The Institute for Genomic Research, Rockville, MD 20850, USAPatrick Ferris - Plant Biology Laboratory, Salk Institute, La Jolla, CA 92037, USAErika Lindquist - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAHarris Shapiro - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USASusan M Lucas - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAJane Grimwood - Stanford Human Genome Center, Stanford University School of Medicine, Palo Alto, CA 94304, USAJeremy Schmutz - Stanford Human Genome Center, Stanford University School of Medicine, Palo Alto, CA 94304, USAPierre Cardol - CNRS, UMR 7141, CNRS/Université Paris 6, Institut de Biologie Physico-Chimique, 75005 Paris, FranceHeriberto Cerutti - University of Nebraska-Lincoln, School of Biological Sciences–Plant Science Initiative, Lincoln, NE 68588, USAGuillaume Chanfreau - Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USAChun-Long Chen - Biotechnology Research Center, Zhongshan University, Guangzhou 510275, ChinaValérie Cognat - Institut de Biologie Moléculaire des Plantes, CNRS, 67084 Strasbourg Cedex, FranceMartin T Croft - Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UKRachel Dent - Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, CA 94720, USASusan Dutcher - Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USAEmilio Fernández - Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Córdoba, Campus de Rabanales, 14071 Córdoba, SpainHideya Fukuzawa - Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, JapanDavid González-Ballester - Department of Plant Biology, Carnegie Institution, Stanford, CA 94306, USADiego González-Halphen - Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México 04510 DF, MexicoArmin Hallmann - Department of Cellular and Developmental Biology of Plants, University of Bielefeld, D-33615 Bielefeld, GermanyMarc Hanikenne - Plant Biology Institute, Department of Life Sciences, University of Liège, B-4000 Liège, BelgiumMichael Hippler - Department of Biology, Institute of Plant Biochemistry and Biotechnology, University of Münster, 48143 Münster, GermanyWilliam Inwood - Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, CA 94720, USAKamel Jabbari - CNRS UMR 8186, Département de Biologie, Ecole Normale Supérieure, 75230 Paris, FranceMing Kalanon - Plant Cell Biology Research Centre, The School of Botany, The University of Melbourne, Parkville, Melbourne, VIC 3010, AustraliaRichard Kuras - CNRS, UMR 7141, CNRS/Université Paris 6, Institut de Biologie Physico-Chimique, 75005 Paris, FrancePaul A Lefebvre - Department of Plant Biology, University of Minnesota, St. Paul MN 55108, USAStéphane D Lemaire - Institut de Biotechnologie des Plantes, UMR 8618, CNRS/Université Paris-Sud, Orsay, FranceAlexey V Lobanov - Department of Biochemistry, N151 Beadle Center, University of Nebraska, Lincoln, NE 68588–0664, USAMartin Lohr - Institut für Allgemeine Botanik, Johannes Gutenberg-Universität, 55099 Mainz, GermanyAndrea Manuell - Department of Cell Biology and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA 92037, USAIris Meier - PCMB and Plant Biotechnology Center, Ohio State University, Columbus, OH 43210, USALaurens Mets - Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USAMaria Mittag - Institut für Allgemeine Botanik und Pflanzenphysiologie, Friedrich-Schiller-Universität Jena, 07743 Jena, GermanyTelsa Mittelmeier - Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USAJames V Moroney - Department of Biological Science, Louisiana State University, Baton Rouge, LA 70803, USAJeffrey Moseley - Department of Plant Biology, Carnegie Institution, Stanford, CA 94306, USACarolyn Napoli - Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USAAurora M Nedelcu - Department of Biology, University of New Brunswick, Fredericton, NB, Canada E3B 6E1Krishna Niyogi - Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, CA 94720, USASergey V Novoselov - Department of Biochemistry, N151 Beadle Center, University of Nebraska, Lincoln, NE 68588–0664, USAIan T Paulsen - The Institute for Genomic Research, Rockville, MD 20850, USAGreg Pazour - Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01605, USASaul Purton - Department of Biology, University College London, London WC1E 6BT, UKJean-Philippe Ral - Unité de Glycobiologie Structurale et Fonctionnelle, UMR8576 CNRS/USTL, IFR 118, Université des Sciences et Technologies de Lille, Cedex, FranceDiego Mauricio Riaño-Pachón - Universität Potsdam, Institut für Biochemie und Biologie, D-14476 Golm, GermanyWayne Riekhof - Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USALinda Rymarquis - Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USAMichael Schroda - Institute of Biology II/Plant Biochemistry, 79104 Freiburg, GermanyDavid Stern - Boyce Thompson Institute for Plant Research at Cornell University, Ithaca, NY 14853, USAJames Umen - Plant Biology Laboratory, Salk Institute, La Jolla, CA 92037, USARobert Willows - Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney 2109, AustraliaNedra Wilson - Department of Anatomy and Cell Biology, Oklahoma State University, Center for Health Sciences, Tulsa, OK 74107, USASara Lana Zimmer - Boyce Thompson Institute for Plant Research at Cornell University, Ithaca, NY 14853, USAJens Allmer - Izmir Ekonomi Universitesi, 35330 Balcova-Izmir TurkeyJanneke Balk - Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UKKaterina Bisova - Institute of Microbiology, Czech Academy of Sciences, Czech RepublicChong-Jian Chen - Biotechnology Research Center, Zhongshan University, Guangzhou 510275, ChinaMarek Elias - Department of Plant Physiology, Faculty of Sciences, Charles University, 128 44 Prague 2, Czech RepublicKarla Gendler - Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USACharles Hauser - Bioinformatics Program, St. Edward's University, Austin, TX 78704, USAMary Rose Lamb - Department of Biology, University of Puget Sound, Tacoma, WA 98407, USAHeidi Ledford - Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, CA 94720, USAJoanne C Long - Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USAJun Minagawa - Institute of Low-Temperature Science, Hokkaido University, 060-0819, JapanM. Dudley Page - Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USAJunmin Pan - Department of Biology, Tsinghua University, Beijing, China 100084Wirulda Pootakham - Department of Plant Biology, Carnegie Institution, Stanford, CA 94306, USAAnnkatrin Rose - Appalachian State University, Boone, NC 28608, USAEric Stahlberg - PCMB and Plant Biotechnology Center, Ohio State University, Columbus, OH 43210, USAAimee M Terauchi - Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USAPinfen Yang - Department of Biology, Marquette University, Milwaukee, WI 53233, USASteven Ball - UMR8576 CNRS, Laboratory of Biological Chemistry, 59655 Villeneuve d'Ascq, FranceChris Bowler - CNRS UMR 8186, Département de Biologie, Ecole Normale Supérieure, 75230 Paris, FranceCarol L Dieckmann - Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USAVadim N Gladyshev - Department of Biochemistry, N151 Beadle Center, University of Nebraska, Lincoln, NE 68588–0664, USAPamela Green - Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USARichard Jorgensen - Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USAStephen Mayfield - Department of Cell Biology and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA 92037, USABernd Mueller-Roeber - Universität Potsdam, Institut für Biochemie und Biologie, D-14476 Golm, GermanySathish Rajamani - Graduate Program in Biophysics, Ohio State University, Columbus, OH 43210, USARichard T Sayre - PCMB and Plant Biotechnology Center, Ohio State University, Columbus, OH 43210, USAPeter Brokstein - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAInna Dubchak - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USADavid Goodstein - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USALeila Hornick - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAY. Wayne Huang - United States Department of EnergyJinal Jhaveri - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAYigong Luo - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USADiego Martínez - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAWing Chi Abby Ngau - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USABobby Otillar - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAAlexander Poliakov - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAAaron Porter - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USALukasz Szajkowski - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAGregory Werner - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAKemin Zhou - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAIgor V Grigoriev - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USADaniel S Rokhsar - U.S. Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USAArthur R Grossman - Department of Plant Biology, Carnegie Institution, Stanford, CA 94306, USA
- Publication Details
- Science (American Association for the Advancement of Science), Vol.318(5848), pp.245-250
- Academic Unit
- Institute of Biological Chemistry
- Number of pages
- 6
- Identifiers
- 99900547062701842
- Language
- English
- Resource Type
- Accepted manuscript