Accepted manuscript
Vitamin or mineral supplement intake and the risk of head and neck cancer: pooled analysis in the INHANCE consortium
International journal of cancer, Vol.131(7), pp.1686-1699
10/01/2012
Handle:
https://hdl.handle.net/2376/116861
PMCID: PMC3376697
PMID: 22173631
Abstract
To investigate the potential role of vitamin or mineral supplementation on the risk of head and neck cancer (HNC), we analyzed individual-level pooled data from 12 case-control studies (7,002 HNC cases and 8,383 controls) participating in the International Head and Neck Cancer Epidemiology consortium. There were a total of 2,028 oral cavity cancer, 2,465 pharyngeal cancer, and 874 unspecified oral/pharynx cancer, 1,329 laryngeal cancer and 306 overlapping HNC cases. Odds ratios (OR) and 95% confidence intervals (CIs) for self reported ever use of any vitamins, multivitamins, vitamin A, vitamin C, vitamin E, and calcium, beta-carotene, iron, selenium, and zinc supplements were assessed. We further examined frequency, duration and cumulative exposure of each vitamin or mineral when possible and stratified by smoking and drinking status. All ORs were adjusted for age, sex, race/ethnicity, study center, education level, and pack-years of smoking, frequency of alcohol drinking and fruit/vegetable intake. A decreased risk of HNC was observed with ever use of vitamin C (OR=0.76, 95% CI=0.59-0.96) and with ever use of calcium supplement (OR=0.64, 95% CI=0.42-0.97). The inverse association with HNC risk was also observed for 10 or more years of vitamin C use (OR=0.72, 95% CI=0.54-0.97) and more than 365 tablets of cumulative calcium intake (OR=0.36, 95% CI=0.16-0.83), but linear trends were not observed for the frequency or duration of any supplement intake. We did not observe any strong associations between vitamin or mineral supplement intake and the risk of head and neck cancer.
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Details
- Title
- Vitamin or mineral supplement intake and the risk of head and neck cancer: pooled analysis in the INHANCE consortium
- Creators
- Qian Li - National Office of Cancer Prevention and Control, Cancer Hospital/Institute, Chinese Academy of Medical Sciences, Beijing, ChinaPhilip Lazarus - Penn State College of Medicine, Hershey, PA, USAShu-chun Chuang - International Agency for Research on Cancer, Lyon, FranceJose Eluf Neto - Universidade de Sao Paulo, Sao Paulo, BrazilAna Menezes - Universidade Federal de Pelotas, Pelotas, BrazilElena Matos - Institute of Oncology Angel H. Roffo, University of Buenos Aires, ArgentinaSergio Koifman - Escola Nacional de Saude Publica, Fundaçao Oswaldo Cruz, Rio de Janeiro, BrazilVictor Wünsch-Filho - Universidade de Sao Paulo, Sao Paulo, BrazilLeticia Fernandez - Institute of Oncology and Radiobiology, Havana, CubaAlexander W Daudt - Hospital de Clinicas de Porto Alegre, Porto Alegre, BrazilMaria Paula Curado - International Prevention Research Institute, Lyon, FranceDeborah M Winn - National Cancer Institute, Bethesda, MD, USASilvia Franceschi - International Agency for Research on Cancer, Lyon, FranceRolando Herrero - Instituto de Investigación Epidemiológica, San José, Costa RicaXavier Castellsague - Institut Català d’Oncologia (ICO), IDIBELL, CIBER-ESP, L’Hospitalet de Llobregat, SpainHal Morgenstern - Departments of Epidemiology and Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USAZuo-Feng Zhang - UCLA School of Public Health, Los Angeles, CA, USAJoshua Muscat - Penn State College of Medicine, Hershey, PA, USAMichael McClean - Boston University School of Public Health, Boston, MA, USAKarl T Kelsey - Brown University, Providence, Rhode Island, USARichard B Hayes - New York University School of Medicine, New York, NY, USAMark P Purdue - National Cancer Institute, Bethesda, MD, USAStephen M Schwartz - Fred Hutchinson Cancer Research Center, Seattle, WA, USAChu Chen - Fred Hutchinson Cancer Research Center, Seattle, WA, USASimone Benhamou - National Institute of Health and Medical Research, Paris, FranceAndrew F Olshan - University of North Carolina School of Public Health, Chapel Hill, NC, USAGuopei Yu - New York Eye and Ear Infirmary, New York, NY, USAStimson Schantz - New York Eye and Ear Infirmary, New York, NY, USAGilles Ferro - International Agency for Research on Cancer, Lyon, FrancePaul Brennan - International Agency for Research on Cancer, Lyon, FrancePaolo Boffetta - International Prevention Research Institute, Lyon, FranceMia Hashibe - International Agency for Research on Cancer, Lyon, France
- Publication Details
- International journal of cancer, Vol.131(7), pp.1686-1699
- Academic Unit
- Department of Pharmaceutical Sciences
- Publisher
- Wiley
- Number of pages
- 14
- Grant note
- R03 DE016611-02 || DE / National Institute of Dental and Craniofacial Research : NIDCR R03 DE016611-01 || DE / National Institute of Dental and Craniofacial Research : NIDCR R03 CA113157-02 || CA / National Cancer Institute : NCI R03 CA113157-01 || CA / National Cancer Institute : NCI
- Identifiers
- 99900547957201842
- Language
- English
- Resource Type
- Accepted manuscript