Book chapter
Alcohol Consumption and Antitumor Immunity: Dynamic Changes from Activation to Accelerated Deterioration of the Immune System
Biological Basis of Alcohol-Induced Cancer, pp.313-331
Advances in Experimental Medicine and Biology, Springer International Publishing
11/10/2014
Handle:
https://hdl.handle.net/2376/108797
PMID: 25427915
Abstract
The molecular mechanisms of how alcohol and its metabolites induce cancer have been studied extensively. However, the mechanisms whereby chronic alcohol consumption affects antitumor immunity and host survival have largely been unexplored. We studied the effects of chronic alcohol consumption on the immune system and antitumor immunity in mice inoculated with B16BL6 melanoma and found that alcohol consumption activates the immune system leading to an increase in the proportion of IFN-γ-producing NK, NKT, and T cells in mice not injected with tumors. One outcome associated with enhanced IFN-γ activation is inhibition of melanoma lung metastasis. However, the anti-metastatic effects do not translate into increased survival of mice bearing subcutaneous tumors. Continued growth of the subcutaneous tumors and alcohol consumption accelerates the deterioration of the immune system, which is reflected in the following: (1) inhibition in the expansion of memory CD8+ T cells, (2) accelerated decay of Th1 cytokine-producing cells, (3) increased myeloid-derived suppressor cells, (4) compromised circulation of B cells and T cells, and (5) increased NKT cells that exhibit an IL-4 dominant cytokine profile, which is inhibitory to antitumor immunity. Taken together, the dynamic effects of alcohol consumption on antitumor immunity are in two opposing phases: the first phase associated with immune stimulation is tumor inhibitory and the second phase resulting from the interaction between the effects of alcohol and the tumor leads to immune inhibition and resultant tumor progression.
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Details
- Title
- Alcohol Consumption and Antitumor Immunity: Dynamic Changes from Activation to Accelerated Deterioration of the Immune System
- Creators
- Hui Zhang - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, USAZhaohui Zhu - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, USAFaya Zhang - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, USAGary G Meadows - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, USA
- Publication Details
- Biological Basis of Alcohol-Induced Cancer, pp.313-331
- Academic Unit
- Pharmaceutical Sciences, Department of
- Series
- Advances in Experimental Medicine and Biology
- Publisher
- Springer International Publishing; Cham
- Identifiers
- 99900547381901842
- Language
- English
- Resource Type
- Book chapter