Book chapter
Developmental Epigenetic Analysis of Sperm
Encyclopedia of Reproduction, pp.239-244
Elsevier Inc, Second Edition
2018
Abstract
The sperm contains a highly unique and specialized epigenetic landscape offering a great degree of interesting research opportunities. The mature sperm epigenome represents remnant marks used throughout spermatogenesis to generate sperm cells competent to perform their function, but also marks that appear to be useful beyond fertilization for embryo development. Because of its unique nature, the sperm epigenome and the marks which seem to reflect alterations or perturbations in spermatogenesis are thought to provide a predictive insight. Emerging data suggest that DNA methylation, non-coding RNAs and histone modifications in sperm can offer more predictive power than the traditional assessments of male infertility. This chapter will focus on the different epigenetic marks and their potential use in the context of male fertility.
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Details
- Title
- Developmental Epigenetic Analysis of Sperm
- Creators
- Deepika Kubsad - Washington State UniversityMillissia Ben Maamar - Washington State UniversityMichael K. Skinner - Washington State University
- Publication Details
- Encyclopedia of Reproduction, pp.239-244
- Academic Unit
- Biological Sciences, School of
- Publisher
- Elsevier Inc
- Edition
- Second Edition
- Identifiers
- 99901080307801842
- Language
- English
- Resource Type
- Book chapter