Book chapter
Environment and the Epigenetic Transgenerational Inheritance of Disease
Caister Academic Press eBooks, pp.297-305
Caister Academic Press
01/01/2015
Abstract
Environmental factors can lead to transgenerational epigenetic changes in generations originating from ancestors exposed to environmental insults such as toxicants, abnormal nutrition or stress. These epigenetic germline changes can in turn increase disease susceptibility in offspring of exposed ancestors. The focus of this chapter is on environmentally induced epigenetic transgenerational inheritance of disease. The molecular mechanisms that allow these inherited epimutations to increase disease susceptibility will be reviewed. Environmental exposure specificity and exposure-specific disease development are also discussed.
Metrics
2 Record Views
Details
- Title
- Environment and the Epigenetic Transgenerational Inheritance of Disease
- Creators
- Ingrid Sadler-Riggleman - Washington State UniversityMichael K. Skinner - Washington State Univ, Sch Biol Sci, Ctr Reprod Biol, Pullman, WA 99164 USA
- Contributors
- B P Chadwick (Editor)
- Publication Details
- Caister Academic Press eBooks, pp.297-305
- Academic Unit
- Biological Sciences, School of
- Publisher
- Caister Academic Press; WYMONDHAM
- Number of pages
- 9
- Identifiers
- 99901080307401842
- Language
- English
- Resource Type
- Book chapter