Book chapter
PIP Kinases from the Cell Membrane to the Nucleus
Phosphoinositides I: Enzymes of Synthesis and Degradation, pp.25-59
Subcellular Biochemistry, Springer Netherlands
03/09/2012
Handle:
https://hdl.handle.net/2376/107500
PMID: 22403073
Abstract
Phosphatidylinositol 4,5-bisphosphate (PIP2) is a membrane bound lipid molecule with capabilities to affect a wide array of signaling pathways to regulate very different cellular processes. PIP2 is used as a precursor to generate the second messengers PIP3, DAG and IP3, indispensable molecules for signaling events generated by membrane receptors. However, PIP2 can also directly regulate a vast array of proteins and is emerging as a crucial messenger with the potential to distinctly modulate biological processes critical for both normal and pathogenic cell physiology. PIP2 directly associates with effector proteins via unique phosphoinositide binding domains, altering their localization and/or enzymatic activity. The spatial and temporal generation of PIP2 synthesized by the phosphatidylinositol phosphate kinases (PIPKs) tightly regulates the activation of receptor signaling pathways, endocytosis and vesicle trafficking, cell polarity, focal adhesion dynamics, actin assembly and 3’ mRNA processing. Here we discuss our current understanding of PIPKs in the regulation of cellular processes from the plasma membrane to the nucleus.
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Details
- Title
- PIP Kinases from the Cell Membrane to the Nucleus
- Creators
- Mark Schramp - Department of Pharmacology, School of Medicine and Public Health, 3710 Medical Sciences Center, University of Wisconsin Medical School, Madison, USAAndrew Hedman - Program in Molecular and Cellular Pharmacology, University of Wisconsin-Madison, Madison, USAWeimin Li - Department of Pharmacology, School of Medicine and Public Health, 3710 Medical Sciences Center, University of Wisconsin Medical School, Madison, USAXiaojun Tan - Program in Molecular and Cellular Pharmacology, University of Wisconsin-Madison, Madison, USARichard Anderson - Department of Pharmacology, School of Medicine and Public Health, 3710 Medical Sciences Center, University of Wisconsin Medical School, Madison, USA
- Publication Details
- Phosphoinositides I: Enzymes of Synthesis and Degradation, pp.25-59
- Academic Unit
- Biomedical Sciences, Department of
- Series
- Subcellular Biochemistry
- Publisher
- Springer Netherlands; Dordrecht
- Identifiers
- 99900547141201842
- Language
- English
- Resource Type
- Book chapter