Review
ARF6: a newly appreciated player in G protein-coupled receptor desensitization
FEBS Letters, Vol.521(1), pp.3-8
2002
Handle:
https://hdl.handle.net/2376/108303
PMID: 12067715
Abstract
The luteinizing hormone/choriogonadotropin hormone receptor (LH/CG R) signals to regulate ovulation, corpus luteum formation, and fetal survival during pregnancy. Agonist binding to the LH/CG R is poorly reversible, emphasizing the importance of a cellular mechanism to temper signaling by a potentially persistently active receptor. Like other G protein-coupled receptors (GPCRs), signaling by this receptor is modulated by its binding of an arrestin. We have identified ADP ribosylation factor 6 (ARF6) as a protein whose activation state is regulated by the LH/CG R and which functions to regulate the availability of plasma membrane-docked arrestin 2 to this receptor. We hypothesize that ARF6 might also serve GPCRs other than the LH/CG R to regulate the availability of arrestin 2 for receptor desensitization.
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Details
- Title
- ARF6: a newly appreciated player in G protein-coupled receptor desensitization
- Creators
- Mary Hunzicker-Dunn - Department of Cell and Molecular Biology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USAVsevolod V Gurevich - Department of Pharmacology, Vanderbilt University School of Medicine, 454 Robinson Research Building, Nashville, TN 37232, USAJames E Casanova - Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USASutapa Mukherjee - Department of Cell and Molecular Biology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
- Publication Details
- FEBS Letters, Vol.521(1), pp.3-8
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546952301842
- Language
- English
- Resource Type
- Review