Review
Child health, developmental plasticity, and epigenetic programming
Endocrine reviews, Vol.32(2), pp.159-224
2011
Handle:
https://hdl.handle.net/2376/110049
PMCID: PMC3365792
PMID: 20971919
Abstract
Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments. Environmental conditions that are experienced in early life can profoundly influence human biology and long-term health. Developmental origins of health and disease and life-history transitions are purported to use placental, nutritional, and endocrine cues for setting long-term biological, mental, and behavioral strategies in response to local ecological and/or social conditions. The window of developmental plasticity extends from preconception to early childhood and involves epigenetic responses to environmental changes, which exert their effects during life-history phase transitions. These epigenetic responses influence development, cell- and tissue-specific gene expression, and sexual dimorphism, and, in exceptional cases, could be transmitted transgenerationally. Translational epigenetic research in child health is a reiterative process that ranges from research in the basic sciences, preclinical research, and pediatric clinical research. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and the development of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs.
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Details
- Title
- Child health, developmental plasticity, and epigenetic programming
- Creators
- Z Hochberg - Technion - Israel Institute of Technology [Haifa]Robert Feil - Institut de Génétique Moléculaire de MontpellierM Constancia - Department of Obstetrics & Gynecology, Metabolic Research LaboratoriesM Fraga - Centro Nacional BiotecnologiaClaudine Junien - Biologie du développement et reproductionJ.C Carel - U690P Boileau - Service de réanimation néonataleY Le Bouc - Département d'Endocrinologie et Diabétologie PédiatriqueC.L Deal - Service d'EndocrinologieK Lillycrop - Development and Cell BiologyR Scharfmann - U845A Sheppard - National Research Centre for Growth and DevelopmentM Skinner - School of Molecular BiosciencesM Szyf - School of Molecular BiosciencesR.A Waterland - Department of Agriculture Children's Nutrition Research Center (R.A.W.), Departments of Pediatrics and Molecular and Human GeneticsD.J Waxman - Department of BiologyE WhitelawK Ong - Medical Research Council Epidemiology Unit, Institute of Metabolic ScienceK Albertsson-Wikland - Göteborg Pediatric Research Centre
- Publication Details
- Endocrine reviews, Vol.32(2), pp.159-224
- Academic Unit
- Biological Sciences, School of
- Publisher
- Endocrine Society
- Number of pages
- 66
- Grant note
- United States National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA BB/D01235X/2; BB/D01235X/1 / Biotechnology and Biological Sciences Research Council; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) Pfizer Endocrine Care INSERM; Institut National de la Sante et de la Recherche Medicale (Inserm) European Society for Pediatric Endocrinology G0600717B; MC_U106179472 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Universite Pierre et Marie Curie-Paris 6 (UPMC) French Research Agency (ANR); Agence Nationale de la Recherche (ANR) MC_U106179472 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) French National Ministry of Health (PHRC) New Zealand government Agence National de la Recherche; Agence Nationale de la Recherche (ANR) Biomedecine Agency BB/D01235X/2; BB/D01235X/1 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) Association for International Cancer Research Institut National du Cancer; Institut National du Cancer (INCA) France Vaxthuset Foundation for Children
- Identifiers
- 99900547120901842
- Language
- English
- Resource Type
- Review