Review
Circadian Rhythms, Disease and Chronotherapy
Journal of Biological Rhythms , Vol.36(6), pp.503-531
12/2021
PMCID: PMC9197224
PMID: 34547953
Abstract
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The adaptive value of clocks is evident when internal body clocks and daily environmental cycles are mismatched, such as in the case of shift work and jet lag or even mistimed eating, all of which are associated with physiological disruption and disease. Studies with animal and human models have also unraveled an important role of functional circadian clocks in modulating cellular and organismal responses to physiological cues (ex., food intake, exercise), pathological insults (e.g. virus and parasite infections), and medical interventions (e.g. medication). With growing knowledge of the molecular and cellular mechanisms underlying circadian physiology and pathophysiology, it is becoming possible to target circadian rhythms for disease prevention and treatment. In this review, we discuss recent advances in circadian research and the potential for therapeutic applications that take patient circadian rhythms into account in treating disease.
Metrics
1 Record Views
Details
- Title
- Circadian Rhythms, Disease and Chronotherapy
- Creators
- Yool Lee (Author) - Washington State University, Biomedical Sciences, Department ofJeffrey M. Field (Author)Amita Sehgal (Author) - University of Pennsylvania
- Publication Details
- Journal of Biological Rhythms , Vol.36(6), pp.503-531
- Academic Unit
- Elson S. Floyd College of Medicine
- Identifiers
- 99901132541101842
- Language
- English
- Resource Type
- Review