Review
Conservation of amino acid transporters in fungi, plants and animals
Trends in Biochemical Sciences, Vol.27(3), pp.139-147
2002
Handle:
https://hdl.handle.net/2376/115055
PMID: 11893511
Abstract
When comparing the transporters of three completely sequenced eukaryotic genomes –
Saccharomyces cerevisiae,
Arabidopsis thaliana and
Homo sapiens – transporter types can be distinguished according to phylogeny, substrate spectrum, transport mechanism and cell specificity. The known amino acid transporters belong to five different superfamilies. Two preferentially Na
+-coupled transporter superfamilies are not represented in the yeast and
Arabidopsis genomes, whereas the other three groups, which often function as H
+-coupled systems, have members in all investigated genomes. Additional superfamilies exist for organellar transport, including mitochondrial and plastidic carriers. When used in combination with phylogenetic analyses, functional comparison might aid our prediction of physiological functions for related but uncharacterized open reading frames.
When comparing amino acid transporters from Saccharomyces cerevisiae, Arabidopis thaliana and Homo sapiens genomes, five superfamilies of transporters are defined; three of which have members in all investigated genomes.
Metrics
6 Record Views
Details
- Title
- Conservation of amino acid transporters in fungi, plants and animals
- Creators
- Daniel Wipf - ZMBP, Plant Physiology, Auf der Morgenstelle 1, Eberhard-Karls-Universität Tübingen, D-72076 Tübingen, GermanyUwe Ludewig - ZMBP, Plant Physiology, Auf der Morgenstelle 1, Eberhard-Karls-Universität Tübingen, D-72076 Tübingen, GermanyMechthild Tegeder - Washington State University, School of Biological Sciences, Pullman, WA 99164-4236, USADoris Rentsch - Molecular Plant Physiology, Institute of Plant Sciences, Altenbergrain 21, CH-3013 Bern, SwitzerlandWolfgang Koch - ZMBP, Plant Physiology, Auf der Morgenstelle 1, Eberhard-Karls-Universität Tübingen, D-72076 Tübingen, GermanyWolf B Frommer - ZMBP, Plant Physiology, Auf der Morgenstelle 1, Eberhard-Karls-Universität Tübingen, D-72076 Tübingen, Germany
- Publication Details
- Trends in Biochemical Sciences, Vol.27(3), pp.139-147
- Academic Unit
- Biological Sciences, School of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900547749201842
- Language
- English
- Resource Type
- Review