Epigenetic transgenerational actions of environmental factors in disease etiology

Michael K Skinner; Mohan Manikkam; Carlos Guerrero-Bosagna

doi:10.1016/j.tem.2009.12.007

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Epigenetic transgenerational actions of environmental factors in disease etiology

Review

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Peer reviewed

Epigenetic transgenerational actions of environmental factors in disease etiology

Michael K Skinner, Mohan Manikkam and Carlos Guerrero-Bosagna

Trends in endocrinology and metabolism, Vol.21(4), pp.214-222

04/2010

DOI: https://doi.org/10.1016/j.tem.2009.12.007

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https://hdl.handle.net/2376/100290

PMCID: PMC2848884

PMID: 20074974

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Abstract

Environmental Pollutants - adverse effects

Genomic Imprinting

Epigenesis, Genetic

Environmental Pollutants - pharmacology

Environmental Exposure

Disease - etiology

Endocrine Disruptors - adverse effects

DNA Methylation

Abnormalities, Drug-Induced - etiology

Pregnancy

The ability of environmental factors to promote a phenotype or disease state not only in the individual exposed but also in subsequent progeny for successive generations is termed transgenerational inheritance. The majority of environmental factors such as nutrition or toxicants such as endocrine disruptors do not promote genetic mutations or alterations in DNA sequence. However, these factors do have the capacity to alter the epigenome. Epimutations in the germline that become permanently programmed can allow transmission of epigenetic transgenerational phenotypes. This review provides an overview of the epigenetics and biology of how environmental factors can promote transgenerational phenotypes and disease.

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Title: Epigenetic transgenerational actions of environmental factors in disease etiology
Creators: Michael K Skinner - Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4236, USA. skinner@wsu.edu
Mohan Manikkam
Carlos Guerrero-Bosagna
Publication Details: Trends in endocrinology and metabolism, Vol.21(4), pp.214-222
Academic Unit: Biological Sciences, School of
Publisher: Elsevier; United States
Number of pages: 9
Grant note: R01 ES012974-07 / NIEHS NIH HHS R01 ES012974 / NIEHS NIH HHS R01 ES012974-04 / NIEHS NIH HHS
Identifiers: 99900546539101842
Language: English
Resource Type: Review