Review
Epigenetic transgenerational toxicology and germ cell disease
International journal of andrology, Vol.30(4), pp.393-397
08/2007
Handle:
https://hdl.handle.net/2376/106437
PMCID: PMC5940009
PMID: 17705811
Abstract
The ability of an environmental exposure (i.e. endocrine disruptor) during sex determination to reprogramme the male germline and promote an epigenetic transgenerational disease phenotype suggests that environmental factors and compounds may permanently alter the germline epigenome. This epigenetic transgenerational phenomenon will be discussed with respect to adult-onset germline disease (e.g. testicular cancer). A thorough literature review is not provided, rather a perspective is provided on how this epigenetic transgenerational toxicology should be considered in germ cell disease and testicular cancer.
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Details
- Title
- Epigenetic transgenerational toxicology and germ cell disease
- Creators
- Michael K Skinner - Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA, USA. skinner@mail.wsu.edu
- Publication Details
- International journal of andrology, Vol.30(4), pp.393-397
- Academic Unit
- Biological Sciences, School of
- Publisher
- England
- Grant note
- R01 ES012974 / NIEHS NIH HHS
- Identifiers
- 99900546727701842
- Language
- English
- Resource Type
- Review