Review
Molecular Basis for Vaccine Development against the Ehrlichial Pathogen Anaplasma marginale
Parasitology Today, Vol.15(7), pp.281-286
07/01/1999
Handle:
https://hdl.handle.net/2376/106167
PMID: 10377531
Abstract
Anaplasma marginale is a tick-transmitted ehrlichial pathogen causing severe morbidity and mortality in livestock on six continents. Development of safe effective vaccines would be greatly facilitated by identification of the protective immune mechanisms and by understanding how the pathogen evades immune effectors to establish persistent infection. In this article, Guy Palmer and colleagues review recent progress in identifying how defined epitopes induce protective immunity and the role of antigenic variation in these epitopes as a mechanism of persistence.
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Details
- Title
- Molecular Basis for Vaccine Development against the Ehrlichial Pathogen Anaplasma marginale
- Creators
- G.H Palmer - Program in Vector-borne Diseases, Washington State University, Pullman, WA 99164-7040, USAF.R Rurangirwa - Program in Vector-borne Diseases, Washington State University, Pullman, WA 99164-7040, USAK.M Kocan - Department of Anatomy, Pathology and Pharmacology, Oklahoma State University, Stillwater, OK 74078, USAW.C Brown - Program in Vector-borne Diseases, Washington State University, Pullman, WA 99164-7040, USA
- Publication Details
- Parasitology Today, Vol.15(7), pp.281-286
- Academic Unit
- Veterinary Microbiology and Pathology, Department of; Paul G. Allen School for Global Animal Health
- Publisher
- Elsevier B.V
- Identifiers
- 99900546861801842
- Language
- English
- Resource Type
- Review