Review
Nanozyme-Enabled Biomedical Diagnosis: Advances, Trends, and Challenges
Advanced healthcare materials, Vol.14(8), pp.e2401630-n/a
03/01/2025
PMID: 39139016
Abstract
As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared to protein-based enzymes, nanozymes exhibit attractive characteristics of low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them with wide use from biochemical sensing and environmental remediation to medical theranostics. Especially in biomedical diagnosis, the feature of catalytic signal amplification provided by nanozymes makes them function as emerging labels for the detection of biomarkers and diseases, with rapid developments observed in recent years. To provide a comprehensive overview of recent progress made in this dynamic field, here an overview of biomedical diagnosis enabled by nanozymes is provided. This review first summarizes the synthesis of nanozyme materials and then discusses the main strategies applied to enhance their catalytic activity and specificity. Subsequently, representative utilization of nanozymes combined with biological elements in disease diagnosis is reviewed, including the detection of biomarkers related to metabolic, cardiovascular, nervous, and digestive diseases as well as cancers. Finally, some development trends in nanozyme-enabled biomedical diagnosis are highlighted, and corresponding challenges are also pointed out, aiming to inspire future efforts to further advance this promising field.
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Details
- Title
- Nanozyme-Enabled Biomedical Diagnosis: Advances, Trends, and Challenges
- Creators
- Qingzhen Tian - University of South ChinaShu Li - University of South ChinaZheng Tang - University of South ChinaZiyu Zhang - University of South ChinaDan Du - Washington State UniversityXiao Zhang - Washington State UniversityXiangheng Niu - University of South ChinaYuehe Lin - Washington State University
- Publication Details
- Advanced healthcare materials, Vol.14(8), pp.e2401630-n/a
- Academic Unit
- School of Mechanical and Materials Engineering
- Grant note
- S202310555199 / National Training Program of Innovation and Entrepreneurship for Undergraduates 2023RC3168 / Science and Technology Innovation Program of Hunan Province 2023JJ40534 / Natural Science Foundation of Hunan Province 221RGC011 / Start-Up Research Fund of the University of South China
- Identifiers
- 99901227639701842
- Language
- English
- Resource Type
- Review