Review
Sex differences in behavioral effects of cannabinoids
Life sciences (1973), Vol.77(20), pp.2471-2478
2005
Handle:
https://hdl.handle.net/2376/106019
PMID: 15958268
Abstract
This review summarizes the existing literature on sex differences in the effects of cannabinoid drugs on behavior, primarily in the adult rodent. These preclinical studies, taken together with preliminary reports of sex differences in cannabinoid effects in humans, suggest that sex of subject may be an important modulating factor in a variety of cannabinoid effects. When sex differences are found, females are usually more sensitive than males to cannabinoids. Both pharmacokinetic and pharmacodynamic variables may contribute to sex differences in behavioral effects of cannabinoids. Given the significant therapeutic potential of cannabinoid agonists and antagonists — as well as their widespread recreational use — it will be important to determine the reliability and functional significance of, as well as mechanisms underlying sex differences in cannabinoid effects.
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Details
- Title
- Sex differences in behavioral effects of cannabinoids
- Creators
- Rebecca M Craft - Department of Psychology, Washington State University, PO Box 644820 Pullman, WA 99164-4820, USA
- Publication Details
- Life sciences (1973), Vol.77(20), pp.2471-2478
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900546850701842
- Language
- English
- Resource Type
- Review