Review
Sex differences in pain and analgesia: The role of gonadal hormones
European journal of pain, Vol.8(5), pp.397-411
2004
Handle:
https://hdl.handle.net/2376/113956
PMID: 15324772
Abstract
There is now strong evidence for sex differences in pain and analgesia. These differences imply that gonadal steroid hormones such as estradiol and testosterone modulate sensitivity to pain and analgesia. The goal of this review is to present an overview of gonadal steroid modulation of pain and analgesia in animals and humans, and to describe mechanisms by which males' and females' biology may differentially predispose them to pain and to analgesic effects of drugs and stress. Evidence is presented to demonstrate that sex differences in pain and analgesia may be both quantitative and qualitative in nature. Current research suggests that sex-specific management of clinical pain will be a reality in the not-so-distant future.
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Details
- Title
- Sex differences in pain and analgesia
- Creators
- Rebecca M Craft - Department of Psychology, Washington State University, Pullman, WA 99164-4820, USAJeffrey S Mogil - Department of Psychology, McGill University, Montreal, Que., CanadaAnna Maria Aloisi - Department of Physiology, University of Siena, Siena, Italy
- Publication Details
- European journal of pain, Vol.8(5), pp.397-411
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900548114601842
- Language
- English
- Resource Type
- Review