Review
Tuning Atomically Dispersed Metal Sites in Nanozymes for Sensing Applications
Angewandte Chemie International Edition, Vol.64(13), pp.e202424070-n/a
03/24/2025
PMID: 39937141
Abstract
Nanozymes with atomically dispersed metal sites (ADzymes), especially single-atom nanozymes, have attracted widespread attention in recent years due to their unique advantages in mimicking the active sites of natural enzymes. These nanozymes not only maximize exposure of catalytic sites but also possess superior catalytic activity performance, achieving challenging catalytic reactions. These advantages position ADzymes as highly promising candidates in the field of sensing and biosensing. This review summarizes the classification and properties of ADzymes, systematically highlighting some typical regulation strategies involving central metal, coordination environment, etc., to achieve their catalytical activity, specificity, and multifunctionality. Then, we present the recent advances of ADzymes in different sensing fields, including colorimetry, fluorescence, electrochemistry, chemiluminescence, photoelectrochemistry, and electrochemiluminescence. Taking advantage of their unique catalytic performance, the resultant ADzymes show great potential in achieving the goal of sensitivity, selectivity and accuracy for the detection of various targets. Specifically, the underlying mechanisms in terms of signal amplification were discussed in detail. Finally, the current challenges and perspectives on the development of advanced ADzymes are discussed.
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Details
- Title
- Tuning Atomically Dispersed Metal Sites in Nanozymes for Sensing Applications
- Creators
- Mingwang Liu - Central China Normal UniversityWeiqing Xu - Central China Normal UniversityYinjun Tang - Central China Normal UniversityYu Wu - Central China Normal UniversityWenling Gu - Central China Normal UniversityDan Du - Washington State UniversityYuehe Lin - Washington State UniversityChengzhou Zhu - Central China Normal University
- Publication Details
- Angewandte Chemie International Edition, Vol.64(13), pp.e202424070-n/a
- Academic Unit
- School of Mechanical and Materials Engineering
- Grant note
- 22374054 / National Natural Science Foundation of China CCNU22JC006 / Fundamental Research Funds for the Central Universities
- Identifiers
- 99901227842101842
- Language
- English
- Resource Type
- Review