Review
Why we sleep: a theoretical view of sleep function
Sleep Medicine Reviews, Vol.3(2), pp.119-129
1999
Handle:
https://hdl.handle.net/2376/115555
PMID: 15310481
Abstract
We propose that sleep begins within small groups of highly interconnected neurons and is characterized by altered input → output (i→0) relationships for any specific neuronal group. Further, experimental findings suggest that growth factors, released locally in response to neuronal activity, and acting in paracrine and autocrine fashions, induce the altered i→0 relationships. These growth factors also act to provide the structural basis for synapses. Thus, we envision that sleep mechanisms (neural use-dependent induction of growth factors and their subsequent effects on i→0 relationships) cannot be separated from sleep function (growth factor-induced synaptic sculpturing). This mechanism/firnction is envisioned to take place in all areas of the brain, including sleep regulatory circuits as well as throughout the cortex. Finally, the “sleep” of neuronal groups (altered i→o relationships) is coordinated by the known sleep regulatory circuits and activational-projection systems in the brain. The theory extends and integrates existing sleep theories to cover a broader range of phenomena.
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Details
- Title
- Why we sleep: a theoretical view of sleep function
- Creators
- James M Krueger - Washington State University, College of Veterinary Medicine, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, PO Box 646520, Pullman, WA 99164-6520, USAFerenc Obál - Albert Szent-Györgyi Medical University, Department of Physiology, H-6720 Szeged, HungaryJidong Fang - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, USA
- Publication Details
- Sleep Medicine Reviews, Vol.3(2), pp.119-129
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900547996301842
- Language
- English
- Resource Type
- Review