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Rights Statements InC/1.0 , Open Access
Conference poster
Structure determination and verification by NMR of potent microtubule stabilizing compounds isolated from the medicinal plant tacca chantrieri. Possible use in tumors resistant to paclitaxel and doxorubicin.
Washington State University Academic Showcase (Pullman, Washington)
03/27/2010
Handle:
https://hdl.handle.net/2376/3859
Abstract
Tumors resistant to the potent anti-cancer drugs Paclitaxel and Doxorubicin are becoming increasingly problematic in the successful treatment of certain patients. A new class of microtubule stabilizing compounds isolated from plants of the genus Tacca have been found to have excellent anti-cancer activity in vivo against cell lines resistant to drugs of the taxane class. We report the structures of the most active compounds as Taccalonolide A, E, B and N as determined by NMR and comparison with published results as well as the structure of additional active components of differing structural classes.
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Details
- Title
- Structure determination and verification by NMR of potent microtubule stabilizing compounds isolated from the medicinal plant tacca chantrieri. Possible use in tumors resistant to paclitaxel and doxorubicin.
- Creators
- William C. Hiscox (Author)Gregory L. Helms (Author)April L. Risinger (Author)Evelyn M. Jackson (Author)Susan L. Mooberry (Author)
- Conference
- Washington State University Academic Showcase (Pullman, Washington)
- Academic Unit
- WSU Academic Showcase 2009
- Grant note
- Washington State University
- Identifiers
- 99900501529001842
- Copyright
- In copyright ; openAccess ; http://rightsstatements.org/vocab/InC/1.0/ ; http://purl.org/eprint/accessRights/OpenAccess
- Language
- English
- Resource Type
- Conference poster