ANAPLASMA MARGINALE INFECTION OF ROCKY MOUNTAIN WOOD TICKS IS DEPENDENT ON CORE α-(1,3)-FUCOSYLATED N-GLYCANS

Rubikah Vimonish

doi:10.7273/000004404

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ANAPLASMA MARGINALE INFECTION OF ROCKY MOUNTAIN WOOD TICKS IS DEPENDENT ON CORE α-(1,3)-FUCOSYLATED N-GLYCANS

Dissertation

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ANAPLASMA MARGINALE INFECTION OF ROCKY MOUNTAIN WOOD TICKS IS DEPENDENT ON CORE α-(1,3)-FUCOSYLATED N-GLYCANS

Rubikah Vimonish

Washington State University

Doctor of Philosophy (PhD), Washington State University

01/2022

DOI:

https://doi.org/10.7273/000004404

Handle:

https://hdl.handle.net/2376/119563

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Abstract

Anaplasma marginale

Bovine anaplasmosis

Dermacentor andersoni

In vitro tick feeding

Primary tick midgut cell culture

Entomology

Bovine anaplasmosis, caused by Anaplasma marginale, is a tick-borne disease of livestock that causes significant economic loss for the United States and Latin America cattle industries that are estimated to exceed one billion dollars annually. Prevention measures are limited in part due to the lack of understanding of the host-pathogen interaction. A. marginale, invades and replicates in the tick midgut for initial development during tick acquisition feeding. These processes are required for the successful colonization of Dermacentor andersoni and other tick vectors. The molecules that facilitate A. marginale invasion of the tick tissues are logical targets of intervention but are unknown. This dissertation described two independent studies. The first simulates the pathogen transmission cycle in in vitro and the second study identifies molecules involved in A. marginale infection into the tick midgut cells. These findings will provide novel insights into tick-pathogen interactions and may help to overcome current limitations of control strategies for bovine anaplasmosis.

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Title: ANAPLASMA MARGINALE INFECTION OF ROCKY MOUNTAIN WOOD TICKS IS DEPENDENT ON CORE α-(1,3)-FUCOSYLATED N-GLYCANS
Creators: Rubikah Vimonish
Contributors: Massaro Ueti (Advisor)
Kelly Brayton (Advisor)
Susan Noh (Committee Member)
Dana Shaw (Committee Member)
Awarding Institution: Washington State University
Academic Unit: Veterinary Medicine, College of
Theses and Dissertations: Doctor of Philosophy (PhD), Washington State University
Publisher: Washington State University
Number of pages: 78
Identifiers: 99900883237701842
Language: English
Resource Type: Dissertation