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CC BY-ND V4.0, Open Access
Dissertation
BRINGING MOBILITY TO THE MASSES: DEVELOPMENT AND INTEGRATION OF ION MOBILITY WITH MASS ANALYZERS
Washington State University
Doctor of Philosophy (PhD), Washington State University
12/2024
DOI:
https://doi.org/10.7273/000007212
Abstract
Despite its century-long history in scientific circles, ion mobility remains underutilized when compared to more established separation methods (i.e., liquid and gas
chromatography). While ion mobility has advantages in gas-phase conformational determination and faster analysis times, it has only recently begun expanding beyond
security applications and individual research labs toward the greater scientific community. Widespread adoption is partly limited due to the availability of commercial instrumentation and the slow dissemination of experimental designs. Most ion mobility literature lacks the experimental information required to recreate the described instrumentation, directly hindering instrumental reproduction. Moreover, ion mobility often necessitates custom gating schemes and specialized knowledge to integrate with commonly available mass analyzers such as ion traps and time-of-flight systems. These factors directly hinder the widespread adoption of ion mobility as a gas-phase separation methodology. This work outlines the construction of multiple ion mobility systems (traveling wave and drift tube) and introduces gating techniques to facilitate integration with mass analyzers. Additionally, all experimental designs are released openly, providing an accessible alternative to existing setups and commercial solutions.
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Details
- Title
- BRINGING MOBILITY TO THE MASSES
- Creators
- Nathan W. Buzitis
- Contributors
- Brian H. Clowers (Chair)Qian Zhang (Committee Member)Jeremy Lessmann (Committee Member)Adam P. Huntley (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- Department of Chemistry
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Publisher
- Washington State University
- Number of pages
- 150
- Identifiers
- 99901195438801842
- Language
- English
- Resource Type
- Dissertation