Dissertation
Biochemical studies of cardiac calsequestrin: its interaction with pharmaceutical drugs and its deleterious mutations
Washington State University
Doctor of Philosophy (PhD), Washington State University
05/2007
DOI:
https://doi.org/10.7273/000005652
Abstract
Calsequestrin is a high capacity but low affinity Ca ? binding protein located in the lumen of Sarcoplasmic Reticulum (SR) whose primary function is to maintain Ca ? concentration at the level of 10? ~10?? M. Calsequestrin is an essential key protein in the process of muscle contraction by controlling the SR Ca ? release and by serving as a Ca ? sensor for the ryanodine receptor, which is a Ca ? release channel. In this dissertation, the first two chapters are concentrated on the description of drugs and mutational effects on the Ca ? regulatory function of calsequestrin. The last chapter, I report a preliminary structural study of canine cardiac junctin, one of the calsequestrin anchoring proteins, required for mediating the normal operation of Ca ? regulatory function of calsequestrin.
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Details
- Title
- Biochemical studies of cardiac calsequestrin
- Creators
- Eunjung Kim
- Contributors
- ChulHee Kang (Chair)Thomas W Okita (Committee Member) - Washington State University, Institute of Biological ChemistryWilliam B Davis (Committee Member) - Washington State University, School of Molecular BiosciencesJames E. Bruce (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- School of Molecular Biosciences
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Publisher
- Washington State University
- Number of pages
- 111
- Identifiers
- 99901054740101842
- Language
- English
- Resource Type
- Dissertation