Dissertation
COAXIAL EXTRUSION OF HYDROGELS FOR BIOMEDICAL APPLICATIONS
Doctor of Philosophy (PhD), Washington State University
01/2020
Handle:
https://hdl.handle.net/2376/111205
Abstract
3D printing has been focused in the bio-medical field due to its customization capability. Especially tissue engineering and drug delivery are the field focusing on 3D printing technique for bio 3D printing and personalized drug delivery. One common structure type used in both fields is the tubular shape and bi-layer structure. The coaxial needle provides excellent manufacturability on both applications. In this study, we identified the potential of using a coaxial needle to manufacture the tubular and bilayer structure with thermal crosslinking hydrogel and viscoelastic hydrogel instead of chemical crosslinking.
First, the possibility of using thermal hydrogel to addictive engineering was studied. The scaffold with thermal crosslinking hydrogel, gellan gum, was manufactured. The scaffold was tested for mechanical properties and degradation behavior for the potential of applications such as drug delivery, wound dressing, and tissue engineering. Second, the coaxial needle was used to create a bi-layer and tubular shape of the same thermal crosslinking hydrogel. At this stage, the controllability of the outer layer which determines the diffusion rate of drug, or nutrient was determined. The encapsulation of inner fluids was also determined for the future application of drug delivery. Third, we tested other application of coaxial needle. The capability of multi-material extrusion of coaxial needle brings great benefit to manufacturing the personalized oral drug delivery system with easy and cheap manufacturing cost. Last, we identify the extrusion process with the control parameter of the coaxial needle with viscoelastic material. This research provides the guideline of using viscoelastic material to create a bi-layer or tubular structure. This study provides information on the potential of usage of the coaxial needle for future applications such as bioengineering and drug delivery.
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Details
- Title
- COAXIAL EXTRUSION OF HYDROGELS FOR BIOMEDICAL APPLICATIONS
- Creators
- Ilhan Yu
- Contributors
- Kuen-Ren Chen (Advisor)Annie Du (Committee Member)Arda Gozen (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- Mechanical and Materials Engineering, School of
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Number of pages
- 132
- Identifiers
- 99900581411701842
- Language
- English
- Resource Type
- Dissertation